Estrogen Receptors Are Involved in the Neuroprotective Effect of Silibinin in Aβ1–42-Treated Rats
| العنوان: | Estrogen Receptors Are Involved in the Neuroprotective Effect of Silibinin in Aβ1–42-Treated Rats |
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| المؤلفون: | Weiwei Liu, Guo-Dong Yao, Yuko Ushiki-Kaku, Bo Liu, Shin-ichi Tashiro, Shunji Hattori, Takashi Ikejima, Lu Liu, Toshihiko Hayashi, Biao Zhou, Xiao-Yu Song, Lingyu Cui, Mingyu Xia |
| المصدر: | Neurochemical Research. 43:796-805 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, chemistry.chemical_classification, Amyloid, business.industry, Kinase, Flavonoid, Morris water navigation task, Hippocampus, Silibinin, Estrogen receptor, General Medicine, Pharmacology, Biochemistry, Neuroprotection, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, Medicine, business, 030217 neurology & neurosurgery |
| الوصف: | Alzheimer's disease (AD) is a progressive neurodegenerative disease that is characterized by a cascade of pathologic changes. A widely discussed theory indicates that amyloid β (Aβ) peptides are the causative agents of AD. Silibinin, a flavonoid derived from milk thistle, is well known for its hepato-protective activities and we have reported the neuroprotective effects of silibinin. In this study, we investigated the role of estrogen receptors (ERs) in silibinin's neuroprotective effect on Aβ1-42-injected rats. Results of Morris water maze and novel object-recognition tests demonstrated that silibinin significantly attenuated Aβ1-42-induced memory impairment. Silibinin attenuated ERs and PI3K-Akt pathways, as well as modulated mitogen-activated protein kinases in the hippocampus of Aβ1-42-injected rats. Taken together, silibinin is a potential candidate in the treatment of Alzheimer's disease. |
| تدمد: | 1573-6903 0364-3190 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::ff19312dcbc77621d4b4f75f437efa20 https://doi.org/10.1007/s11064-018-2481-3 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........ff19312dcbc77621d4b4f75f437efa20 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15736903 03643190 |
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