Risk of total metachronous advanced neoplasia at surveillance colonoscopy after detection of serrated lesions: a matched case–cohort study
| العنوان: | Risk of total metachronous advanced neoplasia at surveillance colonoscopy after detection of serrated lesions: a matched case–cohort study |
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| المؤلفون: | Roupen Djinbachian, Marie-Lyssa Lafontaine, Joseph C. Anderson, Heiko Pohl, Talia Dufault, Michel Boivin, Mickael Bouin, Daniel von Renteln |
| المصدر: | Endoscopy. |
| بيانات النشر: | Georg Thieme Verlag KG, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Gastroenterology |
| الوصف: | Background Serrated lesions are potential colorectal cancer precursors. This study evaluated the presence of total metachronous advanced neoplasia (T-MAN) at follow-up in patients with index serrated lesions compared with a matched cohort without serrated lesions. Methods Patients aged 45–74 years with serrated lesions were matched 2:1 by sex, age, synchronous polyps, and timing of index colonoscopy, to patients without serrated lesions. The primary outcome was T-MAN (advanced adenoma or high-risk serrated lesion) at follow-up. Secondary outcomes included presence of T-MAN stratified by synchronous polyps and serrated lesion characteristics. Results 1425 patients were included (475 patients, 642 serrated lesions; 950 controls; median follow-up 2.9 versus 3.6 years). Patients with serrated lesions had greater risk of T-MAN than those without (hazard ratio [HR] 6.1, 95 %CI 3.9–9.6). Patients with serrated lesions and high-risk adenoma (HRA) had higher risk of T-MAN than those with HRA alone (HR 2.6, 95 %CI 1.4–4.7); similarly, patients with serrated lesions plus low-risk adenoma (LRA) had higher risk than those with LRA alone (HR 7.0, 95 %CI 2.8–18.4), as did patients with serrated lesions without adenoma compared with no adenoma (HR 14.9, 95 %CI 6.5–34.0). Presence of proximal sessile serrated lesion (SSL; HR 9.3, 95 %CI 5.4–15.9), large SSL (HR 17.8, 95 %CI 7.4–43.3), and proximal large SSL (HR 25.0, 95 %CI 8.8–71.3), but not distal SSL, were associated with greater risk for T-MAN. Conclusion Patients with serrated lesions had higher risk for T-MAN regardless of synchronous adenomas. Patients with serrated lesions and HRA, and those with large or proximal SSLs, were at greatest risk. |
| تدمد: | 1438-8812 0013-726X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::ff8e8ffa1d22b6163060020292d5e7d1 https://doi.org/10.1055/a-2020-6797 |
| رقم الأكسشن: | edsair.doi...........ff8e8ffa1d22b6163060020292d5e7d1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14388812 0013726X |
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