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Higher motor cortical excitability linked to greater cognitive dysfunction in Alzheimer's disease: results from two independent cohorts

التفاصيل البيبلوغرافية
العنوان: Higher motor cortical excitability linked to greater cognitive dysfunction in Alzheimer's disease: results from two independent cohorts
المؤلفون: Daniel Z. Press, Peter J. Fried, Stephanie S. Buss, Siddhesh Zadey, Katherine McDonald, Alvaro Pascual-Leone
المصدر: Neurobiol Aging
بيانات النشر: Elsevier BV, 2021.
سنة النشر: 2021
مصطلحات موضوعية: Male, 0301 basic medicine, Oncology, Aging, medicine.medical_specialty, medicine.medical_treatment, Disease, Neuropsychological Tests, Article, 03 medical and health sciences, Cognition, 0302 clinical medicine, Alzheimer Disease, Internal medicine, medicine, Humans, Dementia, Cognitive Dysfunction, Aged, Retrospective Studies, Motor threshold, business.industry, General Neuroscience, Motor Cortex, Middle Aged, medicine.disease, Transcranial Magnetic Stimulation, Pathophysiology, Transcranial magnetic stimulation, Cross-Sectional Studies, 030104 developmental biology, Cortical Excitability, Cohort, Female, Neurology (clinical), Disease assessment, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, Developmental Biology
الوصف: Prior studies have reported increased cortical excitability in people with Alzheimer’s disease (AD), but findings have been inconsistent, and how excitability relates to dementia severity remains incompletely understood. The objective of this study was to investigate the association between a transcranial magnetic stimulation (TMS) measure of motor cortical excitability and measures of cognition in AD. A retrospective cross-sectional analysis tested the relationship between resting motor threshold (RMT) and the Alzheimer’s Disease Assessment Scale - Cognitive Subscale (ADAS-Cog) across two independent samples of AD participants (a discovery cohort, n=22 and a larger validation cohort, n=129) and a control cohort of cognitively normal adults (n=26). RMT was correlated with ADAS-Cog in the discovery-AD cohort (n=22, β=−.70, p
تدمد: 0197-4580
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0010407163fe3f3e5b908f64af24a1a5
https://doi.org/10.1016/j.neurobiolaging.2021.06.007
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....0010407163fe3f3e5b908f64af24a1a5
قاعدة البيانات: OpenAIRE
الوصف
تدمد:01974580