Targeting Pili in Enterococcal Pathogenesis
| العنوان: | Targeting Pili in Enterococcal Pathogenesis |
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| المؤلفون: | Barrett R. Harvey, Ali Azhdarinia, Holly Robinson, Peng Gao, Eva M. Sevick-Muraca, Nathaniel Wilganowski, Sukhen C. Ghosh, Kavindra V. Singh, Barbara E. Murray, Kenneth L. Pinkston |
| المصدر: | Infection and Immunity. 82:1540-1547 |
| بيانات النشر: | American Society for Microbiology, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | medicine.drug_class, Immunology, Monoclonal antibody, Microbiology, Pilus, Enterococcus faecalis, Fimbriae Proteins, chemistry.chemical_compound, medicine, Animals, Gram-Positive Bacterial Infections, biology, Immunization, Passive, Biofilm, Antibodies, Monoclonal, Endocarditis, Bacterial, biology.organism_classification, Virology, Rats, Disease Models, Animal, Infectious Diseases, chemistry, Biofilms, Fimbriae, Bacterial, Microbial Immunity and Vaccines, Monoclonal, biology.protein, Parasitology, Peptidoglycan, Antibody |
| الوصف: | Passive protection, the administration of antibodies to prevent infection, has garnered significant interest in recent years as a potential prophylactic countermeasure to decrease the prevalence of hospital-acquired infections. Pili, polymerized protein structures covalently anchored to the peptidoglycan wall of many Gram-positive pathogens, are ideal targets for antibody intervention, given their importance in establishing infection and their accessibility to antibody interactions. In this work, we demonstrated that a monoclonal antibody to the major component of Enterococcus faecalis pili, EbpC, labels polymerized pilus structures, diminishes biofilm formation, and significantly prevents the establishment of a rat endocarditis infection. The effectiveness of this anti-EbpC monoclonal provides strong evidence in support of its potential as a preventative. In addition, after radiolabeling, this monoclonal identified the site of enterococcal infection, providing a rare example of molecularly specific imaging of an established bacterial infection and demonstrating the versatility of this agent for use in future diagnostic and therapeutic applications. |
| تدمد: | 1098-5522 0019-9567 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00527cba1b9d14ba6425c5eb8deab106 https://doi.org/10.1128/iai.01403-13 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....00527cba1b9d14ba6425c5eb8deab106 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10985522 00199567 |
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