The Challenge of Antimicrobial Resistance: New Regulatory Tools to Support Product Development
| العنوان: | The Challenge of Antimicrobial Resistance: New Regulatory Tools to Support Product Development |
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| المؤلفون: | John H. Rex, David Tenero, Barry I. Eisenstein, Mark Goldberger, John F. Tomayko |
| المصدر: | Clinical Pharmacology & Therapeutics. 96:166-168 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Pharmacology, Clinical Trials as Topic, medicine.drug_class, Drug discovery, business.industry, Antibiotics, Pipeline (software), Anti-Bacterial Agents, Biotechnology, Antibiotic resistance, Risk analysis (engineering), Drug Resistance, Multiple, Bacterial, Drug Discovery, New product development, medicine, Animals, Humans, Pharmacology (medical), Business, International development |
| الوصف: | The antibiotic pipeline is thin and lacks diversity, particularly for agents targeting Gram-negative pathogens. The reasons for our anemic global development pipeline are often summarized as (i) discovery of new antibiotics is difficult, (ii) clinical development of new antibiotics is difficult, and (iii) the economics for new antibiotics are unfavorable for the developer. Here, we review recent efforts directed at the second of these challenges. |
| تدمد: | 1532-6535 0009-9236 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006281f65fcfa573e095820cbe34520c https://doi.org/10.1038/clpt.2014.107 |
| رقم الأكسشن: | edsair.doi.dedup.....006281f65fcfa573e095820cbe34520c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15326535 00099236 |
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