Association Between Genetic Testing for Hereditary Breast Cancer and Contralateral Prophylactic Mastectomy Among Multiethnic Women Diagnosed With Early-Stage Breast Cancer
| العنوان: | Association Between Genetic Testing for Hereditary Breast Cancer and Contralateral Prophylactic Mastectomy Among Multiethnic Women Diagnosed With Early-Stage Breast Cancer |
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| المؤلفون: | Vicky Ro, Donna Russo, Julia E. McGuinness, Meghna S. Trivedi, Ilana Chilton, Boya Guo, Wendy K. Chung, Rita Kukafka, Tarsha Jones, Katherine D. Crew, Elana Levinson, Carrie Koval, Roshni Rao |
| المصدر: | JCO Oncol Pract |
| بيانات النشر: | American Society of Clinical Oncology (ASCO), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Breast Neoplasms, ORIGINAL CONTRIBUTIONS, Contralateral Prophylactic Mastectomy, Breast cancer, Internal medicine, medicine, Humans, Genetic Testing, Stage (cooking), Mastectomy, Likely pathogenic, Retrospective Studies, Genetic testing, medicine.diagnostic_test, Oncology (nursing), business.industry, Health Policy, medicine.disease, Penetrance, Prophylactic Mastectomy, Female, business, Hereditary Breast Cancer |
| الوصف: | PURPOSE: Increasing usage of multigene panel testing has identified more patients with pathogenic or likely pathogenic (P or LP) variants in low-moderate penetrance genes or variants of uncertain significance (VUS). Our study evaluates the association between genetic test results and contralateral prophylactic mastectomy (CPM) among patients with breast cancer. METHODS: We conducted a retrospective cohort study among women diagnosed with unilateral stage 0-III breast cancer between 2013 and 2020 who underwent genetic testing. We examined whether genetic test results were associated with CPM using multivariable logistic regression models. RESULTS: Among 707 racially or ethnically diverse women, most had benign or likely benign (B or LB) variants, whereas 12.5% had P or LP and 17.9% had VUS. Racial or ethnic minorities were twice as likely to receive VUS. Patients with P or LP variants had higher CPM rates than VUS or B or LB (64.8% v 25.8% v 25.9%), and highest among women with P or LP variants in high-penetrance genes (74.6%). On multivariable analysis, P or LP compared with B or LB variants were significantly associated with CPM (odds ratio = 4.24; 95% CI, 2.48 to 7.26). CONCLUSION: Women with P or LP variants on genetic testing were over four times more likely to undergo CPM than B or LB. Those with VUS had similar CPM rates as B or LB. Our findings suggest appropriate genetic counseling and communication of cancer risk to multiethnic breast cancer survivors. |
| تدمد: | 2688-1535 2688-1527 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::008ffb34b1bd39308b321d371d3e8bcf https://doi.org/10.1200/op.21.00322 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....008ffb34b1bd39308b321d371d3e8bcf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 26881535 26881527 |
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