The structure ofINI 1/hSNF 5RPT 1 and its interactions with the c‐MYC :MAX heterodimer provide insights into the interplay betweenMYC and theSWI /SNF chromatin remodeling complex
| العنوان: | The structure of |
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| المؤلفون: | Susan Sammak, Mark Bycroft, Najoua Hamdani, Giovanna Zinzalla, Mark D. Allen |
| المصدر: | The Febs Journal Allen, M D, Sammak, S, Bycroft, M & Zinzalla, G 2018, ' The structure of INI1/hSNF5 RPT1 and its interactions with the c-MYC:MAX heterodimer provide insights into the interplay between MYC and the SWI/SNF chromatin remodeling complex ', The FEBS Journal, vol. 285, no. 22, pp. 4165-4180 . https://doi.org/10.1111/febs.14660 |
| بيانات النشر: | Wiley, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Models, Molecular, 0301 basic medicine, Chromosomal Proteins, Non-Histone, Protein Conformation, MYC, protein–protein interactions, Crystallography, X-Ray, Biochemistry, DNA-binding protein, Chromatin remodeling, Protein–protein interaction, Proto-Oncogene Proteins c-myc, 03 medical and health sciences, 0302 clinical medicine, Protein Domains, Transcription (biology), transcription factors, Humans, Amino Acid Sequence, Binding site, SMARCB1, Molecular Biology, Transcription factor, INI1/hSNF5/BAF47/SMARCB1 subunit, Binding Sites, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Chemistry, RCUK, Original Articles, SMARCB1 Protein, Cell Biology, BAF/PBAF complexes, SWI/SNF, Cell biology, MRC, 030104 developmental biology, 030220 oncology & carcinogenesis, Original Article, Protein Multimerization |
| الوصف: | c‐MYC and the SWI/SNF chromatin remodeling complex act as master regulators of transcription, and play a key role in human cancer. Although they are known to interact, the molecular details of their interaction are lacking. We have determined the structure of the RPT1 region of the INI1/hSNF5/BAF47/SMARCB1 subunit of the SWI/SNF complex that acts as a c‐MYC‐binding domain, and have localized the interaction regions on both INI1 and on the c‐MYC:MAX heterodimer. c‐MYC interacts with a highly conserved groove on INI1, while INI1 binds to the c‐MYC helix‐loop‐helix region. The binding site overlaps with the c‐MYC DNA‐binding region, and we show that binding of INI1 and E‐box DNA to c‐MYC:MAX are mutually exclusive. |
| وصف الملف: | application/pdf |
| تدمد: | 1742-4658 1742-464X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009439df4eeea66fe366e059de32a928 https://doi.org/10.1111/febs.14660 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....009439df4eeea66fe366e059de32a928 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17424658 1742464X |
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