Perfluorocarbon emulsions radiosensitise brain tumors in carbogen breathing mice with orthotopic GL261 gliomas
| العنوان: | Perfluorocarbon emulsions radiosensitise brain tumors in carbogen breathing mice with orthotopic GL261 gliomas |
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| المؤلفون: | William C. Broaddus, Gregory M. Lanza, Bruce D. Spiess, Carole Grasso, Joel R. Garbow, Dana Reid, Lisa A. Feldman, Melanie J. McConnell, Patries M. Herst, Marie-Sophie Fabre |
| المصدر: | PLoS ONE, Vol 12, Iss 9, p e0184250 (2017) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Radiation-Sensitizing Agents, Pulmonology, Physiology, medicine.medical_treatment, Cancer Treatment, Brain tissue, 030218 nuclear medicine & medical imaging, 0302 clinical medicine, Medicine and Health Sciences, Hypoxia, Neurological Tumors, Fluorocarbons, Multidisciplinary, Brain Neoplasms, Respiration, Glioma, Animal Models, Dose–response relationship, Chemistry, Oncology, Neurology, Experimental Organism Systems, Breathing, 030220 oncology & carcinogenesis, Anesthesia, Physical Sciences, Medicine, Carbogen Breathing, Emulsions, medicine.symptom, Research Article, Chemical Elements, Materials by Structure, Science, Materials Science, Mouse Models, Research and Analysis Methods, 03 medical and health sciences, Model Organisms, Carbogen, Medical Hypoxia, medicine, Survival advantage, Animals, Colloids, Dose-Response Relationship, Drug, business.industry, Biology and Life Sciences, Cancers and Neoplasms, Cell Biology, Hypoxia (medical), Carbon Dioxide, Survival Analysis, Radiation therapy, Mice, Inbred C57BL, Oxygen, Disease Models, Animal, Mixtures, Tumor Hypoxia, business, Physiological Processes |
| الوصف: | BackgroundTumour hypoxia limits the effectiveness of radiation therapy. Delivering normobaric or hyperbaric oxygen therapy elevates pO2 in both tumour and normal brain tissue. However, pO2 levels return to baseline within 15 minutes of stopping therapy.AimTo investigate the effect of perfluorocarbon (PFC) emulsions on hypoxia in subcutaneous and intracranial mouse gliomas and their radiosensitising effect in orthotopic gliomas in mice breathing carbogen (95%O2 and 5%CO2).ResultsPFC emulsions completely abrogated hypoxia in both subcutaneous and intracranial GL261 models and conferred a significant survival advantage orthotopically (Mantel Cox: p = 0.048) in carbogen breathing mice injected intravenously (IV) with PFC emulsions before radiation versus mice receiving radiation alone. Carbogen alone decreased hypoxia levels substantially and conferred a smaller but not statistically significant survival advantage over and above radiation alone.ConclusionIV injections of PFC emulsions followed by 1h carbogen breathing, radiosensitises GL261 intracranial tumors. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00aa61ae88804604a072c177b9410c04 https://doaj.org/article/984688287183442382cb8c5de90e40cd |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....00aa61ae88804604a072c177b9410c04 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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