Neoplasms of the skin are found most often on the face. Malignant tumors of the facial skin pose a challenge in treatment, prohibiting compromises between oncologically responsible surgery and functional plus cosmetic outcome. The incidence of melanoma and nonmelanoma skin cancers is rising. Not all malignancies of the skin need to be treated by surgery. For in situ variants there are other options, such as photodynamic therapy and medical treatment. Knowledge of the clinical manifestation, behavior, and prognosis and histopathologic analysis lead to correct diagnosis and choice of suitable treatment. This article presents a synopsis of nonmelanoma, melanoma, and other cancers of the skin.