Polyarteritis nodosa and Antiglomerular Basement Membrane Disease without Antineutrophil Cytoplasm Antibodies
| العنوان: | Polyarteritis nodosa and Antiglomerular Basement Membrane Disease without Antineutrophil Cytoplasm Antibodies |
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| المؤلفون: | Judy Savige, Oliver Hennessy, Roger Sinclair, Geoffrey S. Kirkland |
| المصدر: | American Journal of Nephrology. 16:442-445 |
| بيانات النشر: | S. Karger AG, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Biopsy, Kidney Glomerulus, Enzyme-Linked Immunosorbent Assay, urologic and male genital diseases, Immunofluorescence, Antibodies, Basement Membrane, Antibodies, Antineutrophil Cytoplasmic, Glomerulonephritis, Humans, Medicine, cardiovascular diseases, Fluorescent Antibody Technique, Indirect, skin and connective tissue diseases, Aged, Autoantibodies, medicine.diagnostic_test, urogenital system, business.industry, Polyarteritis nodosa, Acute Kidney Injury, medicine.disease, Polyarteritis Nodosa, Microscopic Polyarteritis, Nephrology, Female, Renal biopsy, business, Vasculitis, Systemic vasculitis |
| الوصف: | Antiglomerular basement membrane (GBM) antibodies have been described previously in patients with microscopic polyarteritis but not in patients with polyarteritis nodosa alone. Where anti-GBM antibodies occur in microscopic polyarteritis, antineutrophil cytoplasm antibodies (ANCA) are usually present. We describe here a patient with polyarteritis nodosa and anti-GBM antibodies in whom ANCA could not be demonstrated. A 72-year-old woman presented with abdominal pain, diarrhoea and acute renal failure. A renal biopsy showed crescentic glomerulonephritis and linear immunofluorescence of the GBM consistent with anti-GBM disease. In addition, there was evidence of large- and medium-sized vessel vasculitis on abdominal angiography, performed because of persisting abdominal pain. There was no small vessel vasculitis on histological examination of the renal biopsy and ANCA could not be demonstrated by indirect immunofluorescence or ELISA. |
| تدمد: | 1421-9670 0250-8095 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e639ce39d7f1f241407af430ca4e74 https://doi.org/10.1159/000169038 |
| رقم الأكسشن: | edsair.doi.dedup.....00e639ce39d7f1f241407af430ca4e74 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219670 02508095 |
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