Risk assessment of thromboembolic events in hospitalized cancer patients
| العنوان: | Risk assessment of thromboembolic events in hospitalized cancer patients |
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| المؤلفون: | Emma Zattarin, Federico Nichetti, Leonardo Provenzano, Andrea Franza, Filippo de Braud, Luca Lalli, Francesca Ligorio, Luca Porcu, Marco Platania, Giulia Montelatici |
| المصدر: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Physiology, Science, Population, Article, Neoplasms, Thromboembolism, Internal medicine, medicine, Humans, education, Cancer, Aged, Inpatients, education.field_of_study, Multidisciplinary, business.industry, Middle Aged, Stepwise regression, medicine.disease, Predictive value, Increased risk, Oncology, Risk factors, Hemorrhagic complication, Medicine, Female, Observational study, Risk assessment, business |
| الوصف: | Hospitalized cancer patients are at increased risk for Thromboembolic Events (TEs). As untailored thromboprophylaxis is associated with hemorrhagic complications, the definition of a risk-assessment model (RAM) in this population is needed. INDICATE was a prospective observational study enrolling hospitalized cancer patients, with the primary objective of assessing the Negative Predictive Value (NPV) for TEs during hospitalization and within 45 days from discharge of low-grade Khorana Score (KS = 0). Secondary objectives were to assess KS Positive Predictive Value (PPV), the impact of TEs on survival and the development of a new RAM. Assuming 7% of TEs in KS = 0 patients as unsatisfactory percentage and 3% of as satisfactory, 149 patients were needed to detect the favorable NPV with one-sided α = 0.10 and power = 0.80. Stepwise logistic regression was adopted to identify variables included in a new RAM. Among 535 enrolled patients, 153 (28.6%) had a KS = 0. The primary study objective was met: 29 (5.4%) TEs were diagnosed, with 7 (4.6%) cases in the KS = 0 group (NPV = 95.4%, 95% CI 90.8–98.1%; one-sided p = 0.084). However, the PPV was low (5.7%, 95% CI 1.9–12.8%); a new RAM based on albumin (OR 0.34, p = 0.003), log(LDH) (OR 1.89, p = 0.023) and presence of vascular compression (OR 5.32, p |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01355f1ade63f76ef816158c944a447f https://doi.org/10.1038/s41598-021-97659-9 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....01355f1ade63f76ef816158c944a447f |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 20452322 |
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