Persistent Hypoplastic Acute Promyelocytic Leukemia with a Novel Chromosomal Abnormality of 46, XY, t(15;17), t(9;11)(q13;p13)
| العنوان: | Persistent Hypoplastic Acute Promyelocytic Leukemia with a Novel Chromosomal Abnormality of 46, XY, t(15;17), t(9;11)(q13;p13) |
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| المؤلفون: | Hiroko Tsunemine, Hiroshi Akasaka, Takayuki Takahashi, Emiko Sakane, Kiminari Itoh, Hayato Maruoka, Kazuyo Yamamoto, Taiichi Kodaka |
| المصدر: | Journal of Clinical and Experimental Hematopathology. 55:71-76 |
| بيانات النشر: | Japanese Society for Lymphoreticular Tissue Research, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Acute promyelocytic leukemia, Pathology, medicine.medical_specialty, Oncogene Proteins, Fusion, Anemia, T-15, Translocation, Genetic, Fatal Outcome, Leukemia, Promyelocytic, Acute, Bone Marrow, immune system diseases, medicine, Chromosomes, Human, Humans, neoplasms, Aged, 80 and over, Leukopenia, Auer rod, business.industry, Karyotype, General Medicine, medicine.disease, Haematopoiesis, medicine.anatomical_structure, Immunology, Bone marrow, medicine.symptom, business |
| الوصف: | A diagnosis of acute promyelocytic leukemia (APL) is usually made when normal hematopoietic cells are substituted by APL cells. We encountered a unique APL patient who presented with persistent hypoplastic features of APL. An 84-year-old man presented with leukopenia (2.2 × 10(9)/L) and anemia (Hb 12.5 g/dL). Five months later, the bone marrow (BM) was hypoplastic with a normal proportion of blasts and promyelocytes (5.2%), although the latter cells were hypergranular. The karyotype of BM cells was 46, XY, t(15;17)(q22;q12), t(9;11)(q13;p13). Two months later, the BM remained hypoplastic with 8.5% hypergranular promyelocytes, some of which contained faggot of Auer rods. RT-PCR examination yielded the PML-RARα transcript, and its sequencing revealed the breakpoint of PML to be bcr2. The patient was treated with all-trans retinoic acid under a diagnosis of APL with improvement of the bicytopenia. FISH analysis of BM cells yielded a negative result regarding t(15;17), although RT-PCR was positive for PML-RARα mRNA. Six months later, APL recurred with the same karyotypic abnormalities and therapeutic resistance, and the patient died of pneumonia. A persistent hypoplastic state of APL may be a rare event, and the association of t(15;17) and t(9;11) is novel. |
| تدمد: | 1880-9952 1346-4280 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0181d140f6669eca212bea9c797c6b30 https://doi.org/10.3960/jslrt.55.71 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0181d140f6669eca212bea9c797c6b30 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18809952 13464280 |
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