Cells / Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells
| العنوان: | Cells / Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells |
|---|---|
| المؤلفون: | Timea Vadasz, Dirk Schmidt-Arras, Lothar Marischen, Julia Frankenheim, Anja Troeger, Stefan Rose-John, Wulf Schneider-Brachert, Jürgen Fritsch |
| المصدر: | Cells Volume 10 Issue 11 Cells, Vol 10, Iss 3100, p 3100 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Programmed cell death, Cell type, Cell Survival, QH301-705.5, Cell, 610 Medizin, ADAM17 Protein, Cell fate determination, Models, Biological, Jurkat cells, Article, Jurkat Cells, TNF-R1, medicine, Humans, Biology (General), Receptor, Receptors, Tumor Necrosis Factor, Member 25, ddc:610, ADAM17, U937 cell, Tumor Necrosis Factor-alpha, Chemistry, NF-kappa B, U937 Cells, General Medicine, Endocytosis, Cell biology, medicine.anatomical_structure, cell death, Receptors, Tumor Necrosis Factor, Type I, Apoptosis, MCF-7 Cells, Amyloid Precursor Protein Secretases, Signal Transduction |
| الوصف: | Signaling via death receptor family members such as TNF-R1 mediates pleiotropic biological outcomes ranging from inflammation and proliferation to cell death. Pro-survival signaling is mediated via TNF-R1 complex I at the cellular plasma membrane. Cell death induction requires complex IIa/b or necrosome formation, which occurs in the cytoplasm. In many cell types, full apoptotic or necroptotic cell death induction requires the internalization of TNF-R1 and receptosome formation to properly relay the signal inside the cell. We interrogated the role of the enzyme A disintegrin and metalloprotease 17 (ADAM17)/TACE (TNF-α converting enzyme) in death receptor signaling in human hematopoietic cells, using pharmacological inhibition and genetic ablation. We show that in U937 and Jurkat cells the absence of ADAM17 does not abrogate, but rather increases TNF mediated cell death. Likewise, cell death triggered via DR3 is enhanced in U937 cells lacking ADAM17. We identified ADAM17 as the key molecule that fine-tunes death receptor signaling. A better understanding of cell fate decisions made via the receptors of the TNF-R1 superfamily may enable us, in the future, to more efficiently treat infectious and inflammatory diseases or cancer. |
| وصف الملف: | text/html; application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0182e4f54096e1f6aac20cb475bb00b2 https://eplus.uni-salzburg.at/doi/10.3390/cells10113100 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0182e4f54096e1f6aac20cb475bb00b2 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |