The diagnostic value of 11q13 amplification and protein expression in the detection of nodal metastasis from oral squamous cell carcinoma: a systematic review and meta-analysis
| العنوان: | The diagnostic value of 11q13 amplification and protein expression in the detection of nodal metastasis from oral squamous cell carcinoma: a systematic review and meta-analysis |
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| المؤلفون: | Inge Stegeman, Stefan M. Willems, Ron Koole, Pauline M. W. van Kempen, Robert J.J. van Es, Rob Noorlag |
| المصدر: | Virchows Archiv Virchows Archives, 466(4), 363. Springer Verlag |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Pathology, ABERRATION, Biology, DIFFERENT SITES, Nodal metastasis, Pathology and Forensic Medicine, Metastasis, NECK-CANCER, TUMOR, Internal medicine, PROGNOSTIC-SIGNIFICANCE, Biomarkers, Tumor, medicine, Carcinoma, Humans, Cyclin D1, HEAD, Stage (cooking), Molecular Biology, Mouth neoplasm, Nodalmetastasis, TONGUE, medicine.diagnostic_test, Chromosomes, Human, Pair 11, CYCLIN D1 AMPLIFICATION, Head and neck cancer, Gene Amplification, Cell Biology, General Medicine, medicine.disease, Oral cavity, Review and Perspectives, Meta-analysis, stomatognathic diseases, 11q13, Fine-needle aspiration, Lymphatic Metastasis, GENETIC ALTERATIONS, Chromosomal region, Carcinoma, Squamous Cell, Systematic review, Mouth Neoplasms, OVEREXPRESSION |
| الوصف: | Despite improvements in both diagnostic and therapeutic strategies, the prognosis of oral squamous cell carcinoma (OSCC) has not changed significantly over the last decades. Prognosis of OSCC particularly depends on the presence of nodal metastasis in the neck. Therefore, proper determination of the nodal status is pivotal for appropriate treatment. Unfortunately, current available imaging techniques (magnetic resonance imaging or ultrasound even with fine needle aspiration of suspected lymph nodes (LNs)) fail to detect occult nodal disease accurately. Clinicians in head and neck oncology urgently need new diagnostic tools to reliably determine the presence of nodal metastasis of the neck. Gain of the chromosomal region 11q13 is one of the most prominent genetic alterations in head and neck cancer and is associated with poor prognosis and metastasis. The aim of this systematic review and meta-analysis was to determine the diagnostic value of either 11q13 amplification or amplification/protein overexpression of individual genes located on 11q13 to detect nodal metastasis in OSCC. A search was conducted in Pubmed, EMBASE, and Cochrane, and 947 unique citations were retrieved. Two researchers independently screened all articles and only 18 were found to meet our inclusion criteria and were considered of sufficient quality for meta-analysis. Pooled results of those show that both amplification of CCND1 and protein overexpression of cyclin D1 significantly correlate with lymph node metastasis (LNM) in OSCC. In addition, amplification of CCND1 shows a negative predictive value of 80 % in the detection of LNM in early stage OSCCs which are clinically lymph node negative although this evidence is sparse and should be validated in a larger homogeneous cohort of T1-2 OSCC. Electronic supplementary material The online version of this article (doi:10.1007/s00428-015-1719-6) contains supplementary material, which is available to authorized users. |
| وصف الملف: | image/pdf |
| تدمد: | 1432-2307 0945-6317 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01bac4208332b47860ca20e85a89f734 https://doi.org/10.1007/s00428-015-1719-6 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....01bac4208332b47860ca20e85a89f734 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14322307 09456317 |
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