Association of central and peripheral pulse pressure with intermediate cardiovascular phenoytpes
| العنوان: | Association of central and peripheral pulse pressure with intermediate cardiovascular phenoytpes |
|---|---|
| المؤلفون: | Christian Delles, Chiara Taurino, Faiez Zannad, Łukasz Klima, John D. McClure, Cédric Collin, Laura Lonati, Enrico Agabiti Rosei, Tatiana Kuznetsova, Maria Lorenza Muiesan, Kalina Kawecka-Jaszcz, Fernando Martinez, Josep Redon, Olle Melander, Ulf Neisius, Alberto Zanchetti, Patrick Rossignol, Grzegorz Bilo, Jan A. Staessen, Anna F. Dominiczak, M. Schneider, Katarzyna Stolarz-Skrzypek, Stéphane Laurent |
| المساهمون: | Neisius, U, Bilo, G, Taurino, C, Mcclure, J, Schneider, M, Kawecka Jaszcz, K, Stolarz Skrzypek, K, Klima, Å, Staessen, J, Kuznetsova, T, Redon, J, Martinez, F, Rosei, E, Muiesan, M, Melander, O, Zannad, F, Rossignol, P, Laurent, S, Collin, C, Lonati, L, Zanchetti, A, Dominiczak, A, Delles, C |
| المصدر: | Journal of Hypertension Journal of Hypertension; Vol 30 |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, Physiology, intermediate cardiovascular phenotypes, Blood Pressure, 030204 cardiovascular system & hematology, surrogate markers, Cohort Studies, pressure, 0302 clinical medicine, Heart Rate, pulse wave analysis, 030212 general & internal medicine, risk-factors, stage renal-disease, Pulse wave velocity, pulse wave analysi, Middle Aged, Phenotype, Peripheral, Pulse pressure, left ventricular hypertrophy, arterial stiffness, aortic pressure, Aortic pressure, Cardiology, all-cause mortality, Female, Cardiology and Cardiovascular Medicine, Human, Adult, medicine.medical_specialty, Mean arterial pressure, hypertension, collaborative trial acct, pulse wave velocity, intimamedia thickness, Humans, Hypertension, Internal Medicine, brachial blood-pressure, wave reflection, steady component, 03 medical and health sciences, intermediate cardiovascular phenotype, Internal medicine, Heart rate, medicine, intima-media thickness, intimamedia thickne, business.industry, medicine.disease, Blood pressure, Intima-media thickness, Arterial stiffness, Cohort Studie, business |
| الوصف: | Objective: We assessed the relationship between pulse pressure and intermediate cardiovascular phenotypes in a middle-aged cohort with high prevalence of hypertension. Background: It has been suggested that central pulse pressure (cPP) is a better predictor of cardiovascular outcome than peripheral pulse pressure (pPP), particularly in the elderly. Yet, it is unclear if cPP provides additional prognostic information to pPP in younger individuals. Methods: In 535 individuals we assessed cPP and pPP as well as the intermediate cardiovascular phenotypes pulse wave velocity (PWV; SphygmoCor, Complior, PulsePen), carotid intima-media thickness (C-IMT; carotid ultrasound), left-ventricular mass index (LVMI; echocardiography) and urinary albumin : creatinine ratio (ACR). cPP was derived noninvasively from brachial blood pressure by pulse wave analysis (PWA; SphygmoCor) based on radial pulse wave tonometry and a validated transfer function. Results: The cohort contained 331 hypertensive participants of whom 84% were treated. The average age was 46 ± 16 years. When compared to pPP, cPP had stronger associations with PWV (r = 0.471 vs. r = 0.372; P < 0.01), C-IMT (r = 0.426 vs. r = 0.235; P < 0.01) and LVMI (r = 0.385 vs. r = 0.189; P < 0.01), but equal association with ACR (r = 0.236 vs. r = 0.226; P = n.s.). In contrast, after adjustment for age, mean arterial pressure, heart rate and hypertension status there was no significant difference between cPP and pPP for prediction of PWV (adjusted R, 0.399 vs. 0.413; P = 0.066), C-IMT (adjusted R, 0.399 vs. 0.413; P = 0.487) and LVMI (adjusted R 2, 0.181 vs. 0.170; P = 0.094) in multivariate analysis. Conclusion: In our middle-aged cohort with high prevalence of hypertension cPP is more closely correlated with cardiovascular phenotypes than pPP. When adjusted for relevant cofactors, however, cPP does not provide additional information beyond pPP. © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins. |
| وصف الملف: | |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c858caac8ae0c5a38e09ed0a27daf9 http://hdl.handle.net/10281/163471 |
| حقوق: | RESTRICTED |
| رقم الأكسشن: | edsair.doi.dedup.....01c858caac8ae0c5a38e09ed0a27daf9 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |