The ATP-Releasing Maxi-Cl Channel: Its Identity, Molecular Partners, and Physiological/Pathophysiological Implications
| العنوان: | The ATP-Releasing Maxi-Cl Channel: Its Identity, Molecular Partners, and Physiological/Pathophysiological Implications |
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| المؤلفون: | Md. Rafiqul Islam, Yasunobu Okada, Nargiza A. Tsiferova, Ranokhon Sh. Kurbannazarova, Petr G. Merzlyak, Toshiaki Okada, Ravshan Z. Sabirov |
| المصدر: | Life, Vol 11, Iss 509, p 509 (2021) Life |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cell signaling, Science, SLCO2A1, Review, General Biochemistry, Genetics and Molecular Biology, diseases, biophysical properties, Dephosphorylation, ATP release, ANXA2, glutamate release, Extracellular, Secretion, Ecology, Evolution, Behavior and Systematics, maxi-anion channels, biology, Chemistry, S100A10, Paleontology, Maxi-Cl, Purinergic signalling, Cell biology, Space and Planetary Science, biology.protein, Signal transduction, Annexin A2, purinergic signaling |
| الوصف: | The Maxi-Cl phenotype accounts for the majority (app. 60%) of reports on the large-conductance maxi-anion channels (MACs) and has been detected in almost every type of cell, including placenta, endothelium, lymphocyte, cardiac myocyte, neuron, and glial cells, and in cells originating from humans to frogs. A unitary conductance of 300–400 pS, linear current-to-voltage relationship, relatively high anion-to-cation selectivity, bell-shaped voltage dependency, and sensitivity to extracellular gadolinium are biophysical and pharmacological hallmarks of the Maxi-Cl channel. Its identification as a complex with SLCO2A1 as a core pore-forming component and two auxiliary regulatory proteins, annexin A2 and S100A10 (p11), explains the activation mechanism as Tyr23 dephosphorylation at ANXA2 in parallel with calcium binding at S100A10. In the resting state, SLCO2A1 functions as a prostaglandin transporter whereas upon activation it turns to an anion channel. As an efficient pathway for chloride, Maxi-Cl is implicated in a number of physiologically and pathophysiologically important processes, such as cell volume regulation, fluid secretion, apoptosis, and charge transfer. Maxi-Cl is permeable for ATP and other small signaling molecules serving as an electrogenic pathway in cell-to-cell signal transduction. Mutations at the SLCO2A1 gene cause inherited bone and gut pathologies and malignancies, signifying the Maxi-Cl channel as a perspective pharmacological target. |
| تدمد: | 2075-1729 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d61921d1340715a84b3ef2f73dacdd https://doi.org/10.3390/life11060509 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....01d61921d1340715a84b3ef2f73dacdd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20751729 |
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