Single-Nucleotide Polymorphisms Related to Leprosy Risk and Clinical Phenotypes Among Chinese Population
العنوان: | Single-Nucleotide Polymorphisms Related to Leprosy Risk and Clinical Phenotypes Among Chinese Population |
---|---|
المؤلفون: | Mei-Wen Yu, Haiqin Jiang, Ying Shi, You-Ming Mei, Pei-Wen Sun, Le Wang, Wenyue Zhang, Si-Yu Long, Jing-Shu Xiong, Hongsheng Wang, Chun Pan, Zhen-Zhen Wang, Zi-Wei Wu, Yanqing Chen, Gai Ge |
المصدر: | Pharmacogenomics and Personalized Medicine |
بيانات النشر: | Informa UK Limited, 2021. |
سنة النشر: | 2021 |
مصطلحات موضوعية: | Pharmacology, Genetics, Lepromatous leprosy, business.industry, Single-nucleotide polymorphism, Genome-wide association study, Immunogenetics, Disease, association study, medicine.disease, Pharmacogenomics and Personalized Medicine, susceptibility gene, Molecular Medicine, Medicine, Leprosy, Allele, polymorphisms, business, leprosy, Original Research, Genetic association |
الوصف: | Si-Yu Long,1 Le Wang,1,2 Hai-Qin Jiang,1 Ying Shi,1 Wen-Yue Zhang,1 Jing-Shu Xiong,1 Pei-Wen Sun,1,2 Yan-Qing Chen,1 You-Ming Mei,1 Chun Pan,1 Gai Ge,1 Zhen-Zhen Wang,1 Zi-Wei Wu,1 Mei-Wen Yu,1,2 Hong-Sheng Wang1â 3 1Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, Peopleâs Republic of China; 2National Centre for Leprosy Control, China CDC, Nanjing, Peopleâs Republic of China; 3Centre for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Peopleâs Republic of ChinaCorrespondence: Hong-Sheng Wang; Mei-Wen YuJiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, St 12 Jiangwangmiao, Nanjing, Jiangsu, 210042, Peopleâs Republic of ChinaEmail whs33@vip.sina.com; yumeiwen@163.comBackground: Genome-wide association studies (GWASs) have identified some immune-related single-nucleotide polymorphisms (SNPs) to be associated with leprosy.Methods: This study investigated the association of 17 SNPs based on previously published GWAS studies with susceptibility to leprosy, different polar forms and immune states of leprosy in a caseâcontrol study from southwestern China, including 1344 leprosy patients and 2732 household contacts (HHCs) (1908 relatives and 824 genetically unrelated contact individuals). The differences of allele distributions were analyzed using chi-squared analysis and logistic regression.Results: After adjusting covariate factors, rs780668 and rs3764147 polymorphisms influenced susceptibilities to genetically related or unrelated leprosy contact individuals. rs142179458 was associated with onset early cases, rs73058713 A allele and rs3764147 A allele increased the risk of reversal reaction, while rs3764147 G allele had higher risk to present lepromatous leprosy and erythema nodosum leprosum.Conclusion: Our results demonstrated that genetic variants in the LACC1, HIF1A, SLC29A3 and CDH18 genes were positively correlated with the occurrence of leprosy and leprosy clinical phenotypes, providing new insights into the immunogenetics of the disease.Keywords: leprosy, association study, susceptibility gene, polymorphisms |
وصف الملف: | text/html |
تدمد: | 1178-7066 1421-7945 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01fd1517762b28b7e41de822ef36ea95 https://doi.org/10.2147/pgpm.s314861 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....01fd1517762b28b7e41de822ef36ea95 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 11787066 14217945 |
---|