Inhibitory effects of peroxisome poliferator-activated receptor gamma on thyroid carcinoma cell growth
| العنوان: | Inhibitory effects of peroxisome poliferator-activated receptor gamma on thyroid carcinoma cell growth |
|---|---|
| المؤلفون: | Ilaria Le Pera, Irene Samà, Lorenzo Chiariotti, Marialuisa Martelli, Simona Cammarota, Alfredo Fusco, Carmen Monaco, Todd G. Kroll, Massimo Santoro, Rodolfo Iuliano |
| المساهمون: | Martelli, Ml, Iuliano, R, Le Pera, I, Sama', I, Monaco, C, Cammarota, S, Kroll, T, Chiariotti, Lorenzo, Santoro, Massimo, Fusco, Alfredo |
| المصدر: | 87 (2002): 4728–4735. info:cnr-pdr/source/autori:Martelli M.L. 1, Iuliano R. 1, Le Pera I. 1, Sama' I.1, Monaco C. 2, Cammarota S. 2, Kroll T. 3, Chiariotti L. 1, Santoro M. 2, Fusco A. 1-2/titolo:Inhibitory effects of peroxisome poliferator-activated receptor gamma on thyroid carcinoma cell growth./doi:/rivista:/anno:2002/pagina_da:4728/pagina_a:4735/intervallo_pagine:4728–4735/volume:87 |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, DNA Mutational Analysis, Thyroid Gland, Peroxisome proliferator-activated receptor, Gene Expression, Receptors, Cytoplasmic and Nuclear, Apoptosis, Cell Cycle Proteins, Biology, Gene mutation, medicine.disease_cause, Transfection, Biochemistry, Thyroid carcinoma, Endocrinology, Internal medicine, medicine, Tumor Cells, Cultured, Humans, Thyroid Neoplasms, Receptor, chemistry.chemical_classification, Cell growth, Reverse Transcriptase Polymerase Chain Reaction, Tumor Suppressor Proteins, Biochemistry (medical), Sequence Analysis, DNA, Cyclin-Dependent Kinases, Thiazoles, Nuclear receptor, chemistry, Adipogenesis, Mutation, Cancer research, lipids (amino acids, peptides, and proteins), Thiazolidinediones, Carcinogenesis, Cell Division, Cyclin-Dependent Kinase Inhibitor p27, Transcription Factors |
| الوصف: | Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor involved in such cellular processes as adipogenesis, inflammation, atherosclerosis, cell cycle control, apoptosis, and carcinogenesis. PPAR gamma gene mutations have been found in 4 of 55 sporadic colon cancers, and a chimeric PAX8-PPAR gamma 1 gene frequently generates a chromosomal translocation in thyroid follicular carcinomas, implicating PPAR gamma in tumor suppression. We investigated whether PPAR gamma is involved in the growth regulation of normal and tumor thyroid cells. We found no mutations in PPAR gamma exons 3 and 5 in human thyroid carcinoma cell lines and tissues. Moreover, 1 cell line (NPA) of 6 analyzed did not express PPAR gamma. Treatment of NPA with PPAR gamma agonists did not induce any inhibitory effect. Conversely, PPAR gamma agonists and PPAR gamma overexpression led to a drastic reduction of the cell growth rate in PPAR gamma-expressing thyroid carcinoma cells. Restoration of PPAR gamma expression in NPA cells induced cell growth inhibition; PPAR gamma agonists induced further inhibition. Growth inhibition induced by PPAR gamma agonists or by PPAR gamma gene overexpression in thyroid carcinoma cells was associated with increased p27 protein levels and apoptotic cell death. Should these data be confirmed, PPAR gamma could be a novel target for innovative therapy of thyroid carcinoma, particularly anaplastic carcinomas, which represent one of the most aggressive tumors in mankind and are unresponsive to conventional therapy. |
| وصف الملف: | STAMPA |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0204113b18a27aea8f2e68cff09a3262 http://hdl.handle.net/11588/470256 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0204113b18a27aea8f2e68cff09a3262 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |