Biomarker development for neonicotinoid exposure in soil under interaction with the synergist piperonyl butoxide in Folsomia candida
| العنوان: | Biomarker development for neonicotinoid exposure in soil under interaction with the synergist piperonyl butoxide in Folsomia candida |
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| المؤلفون: | Ruben Bakker, Astrid Ekelmans, Liyan Xie, Riet Vooijs, Dick Roelofs, Jacintha Ellers, Katja M. Hoedjes, Cornelis A. M. van Gestel |
| المساهمون: | Animal Ecology, Ecological Science |
| المصدر: | Environmental Science and Pollution Research, 29(53), 80897-80909. Springer Bakker, R, Ekelmans, A, Xie, L, Vooijs, R, Roelofs, D, Ellers, J, Hoedjes, K M & van Gestel, C A M 2022, ' Biomarker development for neonicotinoid exposure in soil under interaction with the synergist piperonyl butoxide in Folsomia candida ', Environmental Science and Pollution Research, vol. 29, no. 53, pp. 80897-80909 . https://doi.org/10.1007/s11356-022-21362-z |
| بيانات النشر: | Research Square Platform LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Insecticides, Health, Toxicology and Mutagenesis, Sodium, Imidacloprid, General Medicine, Receptors, Nicotinic, Pollution, Quantitative real-time PCR, Piperonyl butoxide, Soil, Neonicotinoids, Thiacloprid, Animals, Environmental Chemistry, Environmental Pollutants, Pesticides, Arthropods, Biomarkers, Springtails |
| الوصف: | Pesticide toxicity is typically assessed by exposing model organisms to individual compounds and measuring effects on survival and reproduction. These tests are time-consuming, labor-intensive and do not accurately capture the effect of pesticide mixtures. Moreover, it is unfeasible to screen the near infinite combinations of mixtures for synergistic effects on model organisms. Therefore, reliable molecular indicators of pesticide exposure have to be identified, i.e. biomarkers. These biomarkers can form the basis of rapid and economical screening procedures to assess the toxicity of pesticides even under synergistic interaction with other pollutants. In this study, we screened the expression patterns of eight genes for suitability as a biomarker for neonicotinoid exposure in the soil ecotoxicological model Folsomia candida (springtails). Springtails were exposed to the neonicotinoids imidacloprid and thiacloprid either alone or with various levels of piperonyl butoxide (PBO), which inhibits cytochrome P450 enzymes (CYPs): a common point of synergistic interaction between neonicotinoid and other pesticides. First, we confirmed PBO as a potency enhancer for neonicotinoid toxicity to springtail fecundity, and then used it as a tool to confirm biomarker robustness. We identified two genes that are reliably indicative for neonicotinoid exposure even under metabolic inhibition of CYPs by PBO, nicotinic acetylcholine receptor subunit alpha 1 (nAchR) and sodium-coupled monocarboxylate transporter (SMCT). These results can form the basis for developing high-throughput screening procedures for neonicotinoid exposure in varying mixture compositions. |
| تدمد: | 0944-1344 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::020e1b024026ef5dcbc583d54f29d916 https://doi.org/10.21203/rs.3.rs-1298843/v1 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....020e1b024026ef5dcbc583d54f29d916 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 09441344 |
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