Bone growth in the fetus and the neonate : Role of parathyroid hormone-related peptide
| العنوان: | Bone growth in the fetus and the neonate : Role of parathyroid hormone-related peptide |
|---|---|
| المؤلفون: | J.P. Barlet, M.J. Davicco, V. Coxam |
| المساهمون: | Laboratoire de recherches sur la croissance et les métabolismes des herbivores, Institut National de la Recherche Agronomique (INRA), Revues Inra, Import |
| المصدر: | Productions Animales 3 (8), 177-187. (1995) INRA Productions Animales INRA Productions Animales, Paris: INRA, 1995, 8 (3), pp.177-187 Productions animales Productions animales, Institut National de la Recherche Agronomique, 1995, 8 (3), pp.177-187 |
| بيانات النشر: | Universite de Bordeaux, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | [SDV.SA]Life Sciences [q-bio]/Agricultural sciences, PEPTIDE APPARENTE A L'HORMONE PARATHYROIDIENNE, calcium, placenta, IGF 1, os, nouveau né, ruminant, lactation, croissance, lait, transfert calcique, motricité intestinale, Agricultural sciences, phosphore, débit sanguin, [SDV.SA.SPA]Life Sciences [q-bio]/Agricultural sciences/Animal production studies, somatomédine, glande mammaire, [SDV.SA.SPA] Life Sciences [q-bio]/Agricultural sciences/Animal production studies, fœtus, hormones, hormone substitutes, and hormone antagonists, ComputingMilieux_MISCELLANEOUS, Sciences agricoles |
| الوصف: | Le peptide apparenté à l’hormone parathyroïdienne (PTHrP) joue un rôle important dans la régulation de la croissance osseuse foetale et néonatale. Chez la femelle gestante et/ou allaitante, l’hormone sécrétée par les parathyroïdes foetales, les membranes placentaires et/ou la glande mammaire en lactation, stimule les transferts calciques placentaires, module la tonicité utérine en fonction de la taille du (ou des) foetus, contrôle le débit artériel mammaire et la teneur du lait en calcium et en phosphore. Chez le nouveau-né, le PTHrP apporté par le lait pourrait intervenir dans la régulation de la motricité intestinale et de l’absorption intestinale du calcium et du phosphore. Parathyroid hormone-related peptide (PTHrP) plays a major role in the regulation of bone growth in the fetus and the neonate. In pregnant and/or lactating ruminant animals, the PTHrP secreted by fetal parathyroid glands and placental membranes stimulates calcium placental transfer from the dam to the fetus. PTHrP also modulates myometrial uterine activity. The expression of the PTHrP gene in pregnant uterus is under the control of mechanical stretch induced by uterine distension following fetal growth. Thus PTHrP controls the rhytmicity and/or force of myometrial contractions during pregnancy Since uterine contractions severely depress blood flow, another possibility is that PTHrP might act to dilate uterine (and placental) blood vessels and assure adequate blood flow to the uterus and feto-placental unit. Conversely, in ewes and goats, the PTHrP released by the lactating mammary gland regulates mammary blood flow and calcium and phosphorus mammary secretion. In neonates, milk PTHrP might control gut motility and calcium and phosphorus intestinal absorption. Thus, by controling calcium placental transfer, myometrial uterine activity, placental and mammary blood flow, milk calcium and phosphorus concentration, and, possibly, calcium and phosphorus intestinal absorption in the newborn, PTHrP regulates skeletal growth during fetal and postnatal periods. |
| وصف الملف: | application/pdf |
| تدمد: | 2273-7766 2273-774X 0990-0632 1152-5428 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02182ce46535d0e3c0e34e74f3cd9bf8 https://doi.org/10.20870/productions-animales.1995.8.3.4124 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....02182ce46535d0e3c0e34e74f3cd9bf8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22737766 2273774X 09900632 11525428 |
|---|