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Effective expansion of forkhead box P3⁺ regulatory T cells via early secreted antigenic target 6 and antigen 85 complex B from Mycobacterium tuberculosis

التفاصيل البيبلوغرافية
العنوان: Effective expansion of forkhead box P3⁺ regulatory T cells via early secreted antigenic target 6 and antigen 85 complex B from Mycobacterium tuberculosis
المؤلفون: Ying Mu Cai, Li‑Biao Wu, Geng Long Zheng, Zhong‑Ren Du, Ying E. Wu, Gao Zhe Zheng, Wen Guang Peng, Ke Li
المصدر: Molecular medicine reports. 11(4)
سنة النشر: 2014
مصطلحات موضوعية: Adult, Male, Cancer Research, Tuberculosis, Adolescent, Gene Expression, chemical and pharmacologic phenomena, Biochemistry, T-Lymphocytes, Regulatory, Immunophenotyping, Mycobacterium tuberculosis, Young Adult, Immune system, Antigen, Bacterial Proteins, Latent Tuberculosis, Tuberculosis, Multidrug-Resistant, Genetics, medicine, Humans, IL-2 receptor, RNA, Messenger, Molecular Biology, Aged, Antigens, Bacterial, biology, FOXP3, hemic and immune systems, Forkhead Transcription Factors, Middle Aged, bacterial infections and mycoses, biology.organism_classification, medicine.disease, CD4 Lymphocyte Count, Real-time polymerase chain reaction, Phenotype, Oncology, Case-Control Studies, Immunology, Molecular Medicine, Female, Acyltransferases, Mycobacterium
الوصف: The expansion of CD4 + CD25 + forkhead box (FOX)P3 + regulatory T (Treg) cells has been observed in patients with Mycobacterium (M.) tuberculosis; however, the mechanism of expansion remains to be elucidated. The aim of the present study was to examine the role of the early secreted antigenic target 6(ESAT-6) and antigen 85 complex B (Ag85B) from M. tuberculosis on Treg cell expansion. To investigate the sensitivity of peripheral blood cultures to the M. tuberculosis ESAT-6 and Ag85B antigens, the proportion of circulating CD4 + CD25 + FOXP3 + Treg cells was determined using flow cytometry and the levels of FOXP3 mRNA were determined using reverse transcription quantitative polymerase chain reaction. The mRNA levels of FOXP3 and the proportion of circulating CD4 + CD25 + FOXP3 + Treg cells were increased in multiplicitous drug-resistant tuberculosis patients compared with those in healthy controls and patients with latent tuber- culosis (TB) infection (LTBI) (P
تدمد: 1791-3004
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022357c3a28ebf917a3bacf501663e1b
https://pubmed.ncbi.nlm.nih.gov/25483347
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....022357c3a28ebf917a3bacf501663e1b
قاعدة البيانات: OpenAIRE
الوصف
تدمد:17913004