Minimal residual disease-based risk stratification in Chinese childhood acute lymphoblastic leukemia by flow cytometry and plasma DNA quantitative polymerase chain reaction
| العنوان: | Minimal residual disease-based risk stratification in Chinese childhood acute lymphoblastic leukemia by flow cytometry and plasma DNA quantitative polymerase chain reaction |
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| المؤلفون: | Luk, CW, Lee, V, Leung, Y, Ng, MHL, Mejstrikova, E, Hrusak, O, Ling, SC, Li, CH, Lee, ACW, Cheuk, KLD, Ha, SY, Leung, AWK, Shing, MMK, Cheng, CK, Ip, RKL, Chan, NPH, Li, CK, Lau, KM, Cheng, SH |
| المصدر: | PLoS ONE, Vol 8, Iss 7, p e69467 (2013) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Oncology, Male, Pathology, Multivariate analysis, Neoplasm, Residual, Oncogene Proteins, Fusion, lcsh:Medicine, Pediatrics, Polymerase Chain Reaction, Hematologic Cancers and Related Disorders, Molecular cell biology, DNA amplification, Recurrence, hemic and lymphatic diseases, Blood plasma, Antineoplastic Combined Chemotherapy Protocols, Longitudinal Studies, Child, lcsh:Science, Multidisciplinary, medicine.diagnostic_test, Hematology, DNA, Neoplasm, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Flow Cytometry, Acute Lymphoblastic Leukemia, Prognosis, Nucleic acids, medicine.anatomical_structure, Real-time polymerase chain reaction, Child, Preschool, Cohort, Medicine, Female, Research Article, Risk, medicine.medical_specialty, Adolescent, Clinical Research Design, Antineoplastic Agents, Disease-Free Survival, Flow cytometry, Internal medicine, Leukemias, medicine, Humans, Pediatric Hematology, Statistical Methods, Immunoassays, Childhood Acute Lymphoblastic Leukemia, Biology, business.industry, lcsh:R, Infant, DNA, Minimal residual disease, body regions, Pediatric Oncology, Immunologic Techniques, Clinical Immunology, lcsh:Q, Bone marrow, business, Cytometry |
| الوصف: | Minimal residual disease, or MRD, is an important prognostic indicator in childhood acute lymphoblastic leukemia. In ALL-IC-BFM 2002 study, we employed a standardized method of flow cytometry MRD monitoring for multiple centers internationally using uniformed gating, and determined the relevant MRD-based risk stratification strategies in our local patient cohort. We also evaluated a novel method of PCR MRD quantitation using peripheral blood plasma. For the bone marrow flow MRD study, patients could be stratified into 3 risk groups according to MRD level using a single time-point at day-15 (Model I) (I-A: 10%), or using two time-points at day-15 and day-33 (Model II) (II-A: day-15 |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02356b0cfb5c6ef3b26de06ecb3dd81d http://europepmc.org/articles/PMC3723913?pdf=render |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....02356b0cfb5c6ef3b26de06ecb3dd81d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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