Transforming Growth Factor β in Hypertensives With Cardiorenal Damage
| العنوان: | Transforming Growth Factor β in Hypertensives With Cardiorenal Damage |
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| المؤلفون: | Nerea Varo, Javier Díez, C Laviades |
| المصدر: | Hypertension. 36:517-522 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Left ventricular hypertrophy, Essential hypertension, Collagen Type I, Losartan, Muscle hypertrophy, Transforming Growth Factor beta1, N-terminal telopeptide, Transforming Growth Factor beta, Internal medicine, Internal Medicine, medicine, Albuminuria, Humans, Antihypertensive Agents, Proteinuria, business.industry, Angiotensin II, Middle Aged, medicine.disease, Peptide Fragments, Treatment Outcome, Endocrinology, Hypertension, Female, Hypertrophy, Left Ventricular, Microalbuminuria, Collagen, medicine.symptom, Peptides, business, Procollagen, medicine.drug |
| الوصف: | Abstract —We investigated whether a relationship exists between circulating transforming growth factor β -1 (TGF-β 1 ), collagen type I metabolism, microalbuminuria, and left ventricular hypertrophy in essential hypertension and whether the ability of the angiotensin II type 1 receptor antagonist losartan to correct microalbuminuria and regress left ventricular hypertrophy in hypertensives is related to changes in TGF-β 1 and collagen type I metabolism. The study was performed in 30 normotensive healthy controls and 30 patients with never-treated essential hypertension classified into 2 groups: those with microalbuminuria (urinary albumin excretion >30 and 116 g/m 2 for men and >104 g/m 2 for women) (group B; n=17) and those without microalbuminuria or left ventricular hypertrophy (group A; n=13). The measurements were repeated in all patients after 6 months of treatment with losartan (50 mg once daily). The serum concentration of TGF-β 1 was measured by a 2-site ELISA method, and the serum concentrations of carboxy-terminal propeptide of procollagen type I (a marker of collagen type I synthesis) and carboxy-terminal telopeptide of collagen type I (a marker of collagen type I degradation) were measured by specific radioimmunoassays. The duration of hypertension and baseline values of blood pressure were similar in the 2 groups of patients. No differences in serum TGF-β 1 , carboxy-terminal propeptide of procollagen type I, and carboxy-terminal telopeptide of collagen type I were found between normotensives and group A of hypertensives. Serum TGF-β 1 , carboxy-terminal propeptide of procollagen type I, and the ratio of carboxy-terminal propeptide of procollagen type I to carboxy-terminal telopeptide of collagen type I were increased ( P P 1 , carboxy-terminal propeptide of procollagen type I, and the ratio of carboxy-terminal propeptide of procollagen type I to carboxy-terminal telopeptide of collagen type I decreased ( P 1 , stimulation of collagen type I synthesis, inhibition of collagen type I degradation, and cardiorenal damage in a group of patients with essential hypertension. In addition, our results suggest that the ability of losartan to blunt the synthesis of TGF-β 1 and normalize collagen type I metabolism may contribute to protect the heart and the kidney in a fraction of patients with essential hypertension. |
| تدمد: | 1524-4563 0194-911X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0241188bd20bec6c3150f36844ae0f04 https://doi.org/10.1161/01.hyp.36.4.517 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0241188bd20bec6c3150f36844ae0f04 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244563 0194911X |
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