Ceritinib Treatment for Carcinomatous Meningitis with a Secondary Mutation at I1171T in Anaplastic Lymphoma Kinase
| العنوان: | Ceritinib Treatment for Carcinomatous Meningitis with a Secondary Mutation at I1171T in Anaplastic Lymphoma Kinase |
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| المؤلفون: | Masato Shingyoji, Hironori Ashinuma, Sana Yokoi, Yasushi Yoshida, Yuzo Hasegawa |
| المصدر: | Internal Medicine |
| بيانات النشر: | Japanese Society of Internal Medicine, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, 0301 basic medicine, Alectinib, Lung Neoplasms, medicine.medical_treatment, Carbazoles, I1171T, Antineoplastic Agents, Case Report, CSF, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Crizotinib, Piperidines, Carcinoma, Non-Small-Cell Lung, hemic and lymphatic diseases, Internal Medicine, Humans, ceritinib, Medicine, Anaplastic lymphoma kinase, Anaplastic Lymphoma Kinase, alectinib, Sulfones, Lung cancer, Mutation, Ceritinib, business.industry, General Medicine, Resistance mutation, medicine.disease, Radiation therapy, Pyrimidines, 030104 developmental biology, ALK, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer research, Female, business, Meningeal Carcinomatosis, medicine.drug |
| الوصف: | The mechanisms underlying anaplastic lymphoma kinase (ALK) resistance have not been well investigated in clinical practice. We herein report the case of a lung cancer patient with carcinomatous meningitis who had an ALK I1171T resistance mutation revealed by direct DNA sequencing of the cerebrospinal fluid after treatment with cytotoxic chemotherapy, crizotinib, and alectinib. I1171T is considered to be sensitive to ceritinib. Although ceritinib was not effective initially, we chose ceritinib again after whole-brain radiotherapy and ventriculoperitoneal shunting. Although the response duration was short, spinal magnetic resonance imaging revealed a marked response. The identification of an acquired ALK resistance mutation will aid in choosing the optimum sequence therapy. |
| تدمد: | 1349-7235 0918-2918 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c7ecc4c83755031ae65cf4f8872d91 https://doi.org/10.2169/internalmedicine.0397-17 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....02c7ecc4c83755031ae65cf4f8872d91 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13497235 09182918 |
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