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NMR Reveals Functionally Relevant Thermally Induced Structural Changes within the Native Ensemble of G-CSF

التفاصيل البيبلوغرافية
العنوان: NMR Reveals Functionally Relevant Thermally Induced Structural Changes within the Native Ensemble of G-CSF
المؤلفون: Mark-Adam W. Kellerman, Teresa Almeida, Timothy R. Rudd, Paul Matejtschuk, Paul A. Dalby
المصدر: Molecular pharmaceutics. 19(9)
سنة النشر: 2022
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Protein Conformation, Drug Discovery, Granulocyte Colony-Stimulating Factor, Pharmaceutical Science, Molecular Medicine, Proteins, Nuclear Magnetic Resonance, Biomolecular
الوصف: Structure-function relationships in proteins refer to a trade-off between stability and bioactivity, molded by evolution of the molecule. Identifying which protein amino acid residues jeopardize global or local stability for the benefit of bioactivity would reveal residues pivotal to this structure-function trade-off. Here, we use
تدمد: 1543-8392
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02da8cd9bf4422c5c241a8b68ae53b40
https://pubmed.ncbi.nlm.nih.gov/35948076
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....02da8cd9bf4422c5c241a8b68ae53b40
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15438392