Ventricular Function and Tissue Characterization By Cardiac MRI in Children Following Hospitalization for Multisystem Inflammatory Syndrome in Children (MIS-C): A Prospective Study
| العنوان: | Ventricular Function and Tissue Characterization By Cardiac MRI in Children Following Hospitalization for Multisystem Inflammatory Syndrome in Children (MIS-C): A Prospective Study |
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| المؤلفون: | Michael P Dilorenzo, Kanwal M Farooqi, Amee M Shah, Alexandra Channing, Jamie K Harrington, Thomas J Connors, Karen Martirosyan, Usha S Krishnan, Anne Ferris, Rachel J. Weller, Donna L Farber, Joshua D. Milner, Mark Gorelik, Erika B Rosenzweig, Brett R Anderson |
| المصدر: | Research Square article-version (status) pre article-version (number) 1 |
| بيانات النشر: | Research Square Platform LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | cardiovascular system, cardiovascular diseases, Article |
| الوصف: | Background Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe life-threatening manifestation of SARS-CoV-2 infection. Acute cardiac dysfunction and resultant cardiogenic shock are common in children with MIS-C. While most children recover rapidly from acute illness, the long-term impact on the myocardium and cardiac function is unknown. Methods In this prospective study, cardiac MRI (CMR) was performed on patients 10 years old. Native T1 and T2 mapping values were compared with 20 children with normal CMR examinations. Results We performed CMRs on 13 subjects at a median age of 13.6 years (interquartile range [IQR] 11.9-16.0) and a median time from hospitalization of 8.2 months (IQR 6.8-9.6). Twelve subjects displayed normal ventricular function with a median left ventricle ejection fraction (LVEF) of 57.2% (IQR 56.1-58.4) and median right ventricular (RV) EF of 53.1% (IQR 52.0-55.7). One subject had low normal EF (52%). There was normal T2 and native T1 as compared to normal controls. There was qualitatively no evidence of edema by T2 weighted imaging. One subject had late gadolinium enhancement (LGE) at the inferior insertion point and mid-ventricular inferolateral region, with normal EF, no evidence of edema or perfusion defects, and normal T1 and T2 times. When stratifying by a history of abnormal LVEF (LVEF |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ecb27eb953f58cf968a175ecccdb79 https://doi.org/10.21203/rs.3.rs-1254952/v1 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....02ecb27eb953f58cf968a175ecccdb79 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |