Vitamin D levels and mortality with SARS-COV-2 infection: a retrospective two-centre cohort study
| العنوان: | Vitamin D levels and mortality with SARS-COV-2 infection: a retrospective two-centre cohort study |
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| المؤلفون: | Philip Mayhead, Amr Elyasaky, Bipin Pun, Mirej Patel, Reem Eldebri, Nadiyah Zafar, Muhammad Shahbaz, Giulio Ciroi, Bao Khuu, Kamal Lawrence, Maaryah J Zafar, Ojofeitimi Oluwamayowa, Manivannan Periasamy, Lucinda Barry, Mark Whitehead, William W. O'Neill, Ratan Singh Randhawa, Alisha Khanna, Mansoor Zafar, Zahra Maryam, Mohamed Abdelbagi, Mariya Farooq, Saba Alam, Karuna Subba, Andreia Esteves Morete, Dana Safarova, O. A. Makanjuola, B. A. Adekunle, Abubakr Hadid, Mangala Karkhanis, Frderic Cuison, Johannes Hegner, Raphael Golez, Steve Moran, Umesh Dashora, Hesam Nooredinavand, Tila Muhammad |
| المصدر: | Postgraduate Medical Journal |
| بيانات النشر: | Oxford University Press (OUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Vitamin, medicine.medical_specialty, Adolescent, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), porphyria, Cohort Studies, Young Adult, chemistry.chemical_compound, Internal medicine, accident & emergency medicine, Vitamin D and neurology, Humans, Medicine, Prospective Studies, Vitamin D, Child, Prospective cohort study, Aged, Retrospective Studies, Original Research, Aged, 80 and over, SARS-CoV-2, business.industry, Mortality rate, COVID-19, Infant, Vitamins, General Medicine, Middle Aged, internal medicine, chemistry, Child, Preschool, Cohort, haematology, RNA, Viral, business, Cohort study |
| الوصف: | Background The role of vitamin D in increased mortality with SARS-COV-2 virus, namely, COVID-19, remains uncertain. We analysed all the patients who were treated as COVID-19-positive with or without a positive swab and were tested for vitamin D levels. Methods This was a retrospective, study involving 1226 patients swabbed for SARS-CoV-2 between the 10 February 2020 and 1 May 2020 at two hospitals of East Sussex Healthcare NHS Trust. Patients who were swab-positive for COVID-19 or treated as COVID-19-positive on clinical grounds even though swab results were negative were included in this study. We analysed the association of vitamin D levels and mortality, assessing linear and non-linear associations. Results A total of 1226 patients had SARS-CoV-2 RNA swabs in this period with age range from 1 year to 101 years. A cohort of 433 of these patients had swabs and recent vitamin D levels anytime in the previous 3 months. Mortality rates were not found to be associated with vitamin D levels (OR=1.04, 95% CI 0.96 to 1.12). Conclusion Our findings suggest similar mortality risk from COVID-19 irrespective of the levels of vitamin D. Larger prospective studies will be needed to confirm these findings. |
| تدمد: | 1469-0756 0032-5473 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031e0d605191832c0c4a71487ac2f771 https://doi.org/10.1136/postgradmedj-2021-140564 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....031e0d605191832c0c4a71487ac2f771 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14690756 00325473 |
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