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Effects of bacitracin methylene disalicylate and diet change on gastrointestinal integrity and endotoxin permeability in the duodenum of broiler chicken

التفاصيل البيبلوغرافية
العنوان: Effects of bacitracin methylene disalicylate and diet change on gastrointestinal integrity and endotoxin permeability in the duodenum of broiler chicken
المؤلفون: Karen Christensen, H. Lester, Colin G. Scanes, D. A. Koltes, Douglas Aldridge, Maurice Frost
المصدر: BMC Research Notes, Vol 10, Iss 1, Pp 1-6 (2017)
BMC Research Notes
بيانات النشر: Springer Science and Business Media LLC, 2017.
سنة النشر: 2017
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Duodenum, medicine.drug_class, Antibiotics, lcsh:Medicine, Bacitracin, Grower diet, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Internal medicine, Antibiotic free, medicine, Animals, lcsh:Science (General), lcsh:QH301-705.5, Bacitracin methylene disalicylate, 030109 nutrition & dietetics, Growth promoting, Ussing chamber, business.industry, lcsh:R, Broiler, General Medicine, Animal Feed, Salicylates, Anti-Bacterial Agents, Diet, Endotoxins, Research Note, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, lcsh:Biology (General), Morphometric analysis, Animal Nutritional Physiological Phenomena, business, Chickens, Starter diet, lcsh:Q1-390, medicine.drug
الوصف: Objective To determine the effect of bacitracin methylene disalicylate (BMD) and feed changes on gastrointestinal integrity, endotoxin permeability, and morphometric parameters in the duodenum of broilers. Results Birds were raised on a starter diet without growth promoting antibiotics for 31 days then switched to a grower diet. Four of the pens including 50 g/ton of BMD while 4 pens remained antibiotic free. Eight birds per treatment were sampled prior to the feed change and at 3 and 7 days following the feed change. Gastrointestinal integrity and endotoxin permeability in the duodenum were determined using a modified Ussing Chamber and an adjacent section fixed in 10% formalin for morphometric analysis. Data were analyzed using Proc Glimmix of SAS with the model fitting BMD treatment, time, and the interaction of BMD treatment and time as fixed effects. Intestinal integrity increased at d 3 and 7 compared to prior to the feed change and addition of BMD (P > 0.001) and villus height was decreased with BMD supplementation (P = 0.049). All other tested effects similar (P > 0.1). In conclusion, the practice of changing feed had a greater effect on intestinal health than addition of BMD. However, the factors driving these differences 42 are unclear. Electronic supplementary material The online version of this article (doi:10.1186/s13104-017-2781-8) contains supplementary material, which is available to authorized users.
تدمد: 1756-0500
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0330433e750f0e190396225263f4219a
https://doi.org/10.1186/s13104-017-2781-8
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....0330433e750f0e190396225263f4219a
قاعدة البيانات: OpenAIRE
الوصف
تدمد:17560500