Regular surveillance by imaging for early detection and better prognosis of hepatocellular carcinoma in patients infected with hepatitis C virus
| العنوان: | Regular surveillance by imaging for early detection and better prognosis of hepatocellular carcinoma in patients infected with hepatitis C virus |
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| المؤلفون: | Ikue Noda, Ryohei Hayashi, Hiroyasu Yamada, Kazuaki Chayama, Junko Tanaka, Masaru Imagawa, Yoshio Monzen, Tomoaki Okimoto, Nobuhiko Hiraga, Hideki Nakahara, Mikiya Kitamoto |
| المصدر: | Journal of Gastroenterology. 45:105-112 |
| بيانات النشر: | Springer Science and Business Media LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Carcinoma, Hepatocellular, Hepatitis C virus, Contrast Media, medicine.disease_cause, Gastroenterology, Internal medicine, medicine, Carcinoma, Humans, Mass Screening, Survival rate, Aged, Neoplasm Staging, Retrospective Studies, Aged, 80 and over, business.industry, Liver Neoplasms, Retrospective cohort study, Hepatitis C, Middle Aged, Hepatology, Prognosis, medicine.disease, humanities, digestive system diseases, Survival Rate, body regions, Early Diagnosis, Treatment Outcome, Hepatocellular carcinoma, Female, business, Liver cancer |
| الوصف: | This study evaluated the usefulness of regular check-ups by ultrasonography and contrast-enhanced imaging for early detection of hepatocellular carcinoma (HCC) in a retrospective analysis.From April 2001 to March 2007, 240 consecutive patients with HCC who were infected with hepatitis C virus (HCV) were divided into three groups. Patients diagnosed with HCC by repeated imaging constituted Group A (surveillance group). Group B comprised patients in whom HCC was detected during scheduled doctor visits for liver disease or other diseases such as diabetes. Group C comprised non-screened patients.The prevalence of solitary tumors decreased from Group A through Group B to Group C (66, 48 and 24%, respectively, P0.001). The proportion of patients in stages I and II decreased from 83% (103/124) in Group A to 53% (42/79) in Group B and 24% (9/37) in Group C (P0.001). The proportion of patients who were treated with curative procedures, such as resection or ablation, was highest at 80% (99/124) in Group A, and lower at 53% (42/79) in Group B and 27% (10/37) in Group C (P0.001). The cumulative survival rate was better in Group A than B (P0.05), and in Group B than C (P0.001). Periodical medical check-ups without imaging did not necessarily detect early-stage disease, even when HCC-related markers including des-gamma-carboxy prothrombin were tested.Regular surveillance with ultrasonography and contrast-enhanced imaging is useful for detecting early-stage HCC and increase chances for curative treatments in patients with HCV-related chronic liver disease. |
| تدمد: | 1435-5922 0944-1174 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0344e68e41f949a04d2fc384bfe7d458 https://doi.org/10.1007/s00535-009-0131-x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....0344e68e41f949a04d2fc384bfe7d458 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14355922 09441174 |
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