Atypical Chemokine Receptor 1 polymorphism cannot be used as an indicator of liver fibrosis progression in Hepatitis C virus positive patients
| العنوان: | Atypical Chemokine Receptor 1 polymorphism cannot be used as an indicator of liver fibrosis progression in Hepatitis C virus positive patients |
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| المؤلفون: | Shihang Zhou, Weijian Yu, Ming Liu, Lin-Nan Shao, Shu-Ting Zhang |
| المصدر: | Pakistan Journal of Medical Sciences |
| بيانات النشر: | Professional Medical Publications, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Liver damage, Chemokine, Hepatitis C virus, Liver fibrosis, medicine.disease_cause, 03 medical and health sciences, Chemokine receptor, Blood serum, medicine, Serum liver related markers, Polymorphism, biology, business.industry, General Medicine, Hepatitis C, medicine.disease, Atypical chemokine receptor 1, 030104 developmental biology, Hepatitis C Virus Positive, Immunology, biology.protein, Original Article, Hepatic fibrosis, business, Viral hepatitis |
| الوصف: | Background & objective Atypical chemokine receptor 1(ACKR1) represents an atypical chemokine receptor that can bind promiscuously to various chemokines. Chemokines play a crucial role to recruit leukocyte subsets migration through the endothelium and into liver against the virus during the progression of hepatitis C virus (HCV) infection. Most HCV positive patients can lead to liver fibrosis. Hyaluronic acid (HA), laminin (LN), collagen IV(C-IV) and amino-terminal pro-peptide of Type-III pro-collagen (PIII NP) are indices of the extent of liver fibrosis. The aim of this study was to investigate the association between ACKR1 polymorphism and liver fibrosis with these four serum liver markers in HCV positive patients. Methods From April 2015 to December 2015, a total of 210 patients (109 males and 101 females) with chronic HCV infection at Dalian Infectious Hospital were recruited to participate in this study. ACKR1 genotyping was using TaqMan probes method. HA, LN, C-IV and PIII NP were detected by using diagnostic kits. Results We compared serum levels of HA, LN, C-IV and PIII NP between FY*A/FY*A and FY*A/FY*B patients and the differences were not significant (P=0.905, P=0.298, P=0.880 and P=0.470, respectively). Conclusions This study has attempted to elucidate the role of ACKR1 polymorphism in liver fibrosis progression of HCV infection, our results demonstrated that ACKR1 polymorphism is not directly associated with the fibrogenesis in HCV positive patients. |
| اللغة: | English |
| تدمد: | 1681-715X 1682-024X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035f127a12c4f974856188e9f42dcace http://europepmc.org/articles/PMC5673721 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....035f127a12c4f974856188e9f42dcace |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1681715X 1682024X |
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