Expression of survivin and human telomerase reverse transcriptase in extramammary Paget's disease
| العنوان: | Expression of survivin and human telomerase reverse transcriptase in extramammary Paget's disease |
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| المؤلفون: | Ying Guo, Quanzhong Liu, Tingfen Nie, Shi-Jun Shan, Zhe Guo, Naiqin Zhang, Shi-Ling Geng, Zhihai Zhou, Changping Li, Hong-Duo Chen, Xu Chen, Huachen Wei |
| المصدر: | Journal of Cutaneous Pathology. 37:635-640 |
| بيانات النشر: | Wiley, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, Pathology, medicine.medical_specialty, Skin Neoplasms, Histology, Survivin, Population, Dermatology, Biology, Extramammary Paget's disease, Inhibitor of Apoptosis Proteins, Vulva, Pathology and Forensic Medicine, Lesion, Sex Factors, medicine, Humans, Telomerase reverse transcriptase, education, Telomerase, neoplasms, In Situ Hybridization, Aged, Skin, Aged, 80 and over, education.field_of_study, Apocrine, Middle Aged, medicine.disease, Immunohistochemistry, Exact test, Paget Disease, Extramammary, embryonic structures, Scrotum, Female, medicine.symptom, Microtubule-Associated Proteins, Penis |
| الوصف: | BACKGROUND Extramammary Paget's disease (EMPD) is a rare neoplasm of apocrine gland-bearing skin. It is known that over-expression of survivin and human telomerase reverse transcriptase (hTERT) correlates with malignancies. We investigated the expression of hTERT and survivin by Paget's cells and their role in the tissue invasion and recurrence of EMPD. METHOD Forty-two patients were enrolled into the study. Expression of survivin and hTERT were analyzed by immunohistochemistry and in situ hybridization techniques. The variables including the expression level of survivin and hTERT, gender, age, lesion location, invasion level and number of surgeries were statistically analyzed using Fisher's exact test. RESULTS Survivin was positively stained in 18 of 22 cases (81.8%), and hTERT in 18 of 29 cases (62.1%). Significantly higher level of survivin expression was detected in patients with multiple surgeries than those with single one (p = 0.0458). Expression of hTERT was significantly higher in the patients with micro-invasive and invasive lesions than those with non-invasive lesions (p = 0.0478). CONCLUSIONS Over-expression of survivin and hTERT correlated strongly with recurrence and local invasion of EMPD lesions. EMPD has male gender predominance in Oriental population. |
| تدمد: | 1600-0560 0303-6987 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0364c7f2a966edeeec5a0ac9691204ae https://doi.org/10.1111/j.1600-0560.2009.01437.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....0364c7f2a966edeeec5a0ac9691204ae |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16000560 03036987 |
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