التفاصيل البيبلوغرافية
العنوان:
Rapamycin analogs with reduced systemic exposure
المؤلفون:
Noah Tu , Kennan C. Marsh , Karl W. Mollison , Rolf Wagner , Gin C. Hsieh , Cynthia L. Henry , Merrill Nuss , Jay R. Luly , Denise Wilcox , Nwe Y. Bamaung , Benjamin C. Lane , Richard P. Carlson , Yung-Wu Chen , Thomas A. Fey , Luping Liu , Paul E. Wiedeman , Yat-Sun Or , James M. Trevillyan , George W. Carter , Peer B. Jacobson , Teresa A. Rosenberg , Stevan W. Djuric
المصدر:
Bioorganic & Medicinal Chemistry Letters . 15:5340-5343
بيانات النشر:
Elsevier BV, 2005.
سنة النشر:
2005
مصطلحات موضوعية:
Male , Clinical Biochemistry , Pharmaceutical Science , Pharmacology , Biochemistry , Chemical synthesis , Arthritis, Rheumatoid , Rats, Sprague-Dawley , Pharmacokinetics , In vivo , Drug Discovery , medicine , Animals , Molecular Biology , Sirolimus , Chemistry , Organic Chemistry , Biological activity , Rats , Radiography , Safety profile , Rats, Inbred Lew , Antirheumatic Agents , Molecular Medicine , medicine.drug
الوصف:
The synthesis and biological activities of rapamycin (I) analogs modified at the C-40 position are reported. Emphasis placed on compounds that potentially have an improved safety profile on account of their shorter in vivo half-life when compared with rapamycin.
تدمد:
0960-894X
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036756a7d35bbf41755d205775e590ad https://doi.org/10.1016/j.bmcl.2005.06.106
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....036756a7d35bbf41755d205775e590ad
قاعدة البيانات:
OpenAIRE
