A design strategy for small molecule-based targeted MRI contrast agents: their application for detection of atherosclerotic plaques
| العنوان: | A design strategy for small molecule-based targeted MRI contrast agents: their application for detection of atherosclerotic plaques |
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| المؤلفون: | Kazuo Umemura, Keita Tamura, Takuya Terai, Shimpei Iwaki, Kazuya Hokamura, Yasuaki Muramatsu, Kohsuke Hagisawa, Kenjiro Hanaoka, Kazuhisa Hirabayashi, Tetsuo Nagano, Makoto Arita, Yuji Morimoto, Hiroyuki Arai, Yasuo Takehara, Yasunobu Hirata, Toru Komatsu, Kazuhide Nakahara, Tomoko Mineno, Yusuke Adachi, Mikako Ogawa, Tasuku Ueno, Takehiro Yamane |
| المصدر: | Org. Biomol. Chem.. 12:8611-8618 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Boron Compounds, Fluorophore, MRI contrast agent, Gadolinium, Contrast Media, chemistry.chemical_element, Nanotechnology, Biochemistry, Mice, chemistry.chemical_compound, Apolipoproteins E, Coordination Complexes, Lipid droplet, Adipocytes, medicine, Animals, Physical and Theoretical Chemistry, Aorta, Fluorescent Dyes, Mice, Knockout, medicine.diagnostic_test, Chemistry, Organic Chemistry, Magnetic resonance imaging, Lipid Droplets, Magnetic Resonance Imaging, Small molecule, Plaque, Atherosclerotic, Drug Design, Injections, Intravenous, Rabbits, BODIPY, Preclinical imaging, Biomedical engineering |
| الوصف: | Gadolinium(III) ion (Gd(3+)) complexes are widely used as contrast agents in magnetic resonance imaging (MRI), and many attempts have been made to couple them to sensor moieties in order to visualize biological phenomena of interest inside the body. However, the low sensitivity of MRI has made it difficult to develop practical MRI contrast agents for in vivo imaging. We hypothesized that practical MRI contrast agents could be designed by targeting a specific biological environment, rather than a specific protein such as a receptor. To test this idea, we designed and synthesized a Gd(3+)-based MRI contrast agent, 2BDP3Gd, for visualizing atherosclerotic plaques by linking the Gd(3+)-complex to the lipophilic fluorophore BODIPY to stain lipid-rich environments. We found that 2BDP3Gd was selectively accumulated into lipid droplets of adipocytes at the cellular level. Atherosclerotic plaques in the aorta of Watanabe heritable hyperlipidemic (WHHL) rabbits were clearly visualized in T1-weighted MR images after intravenous injection of 2BDP3Gd in vivo. |
| تدمد: | 1477-0539 1477-0520 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03aedadf81f7390aa70906a6a30b4034 https://doi.org/10.1039/c4ob01270d |
| رقم الأكسشن: | edsair.doi.dedup.....03aedadf81f7390aa70906a6a30b4034 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14770539 14770520 |
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