Toxicological properties of two fluorescent carbon quantum dots with onion ring morphology and their usefulness as bioimaging agents
| العنوان: | Toxicological properties of two fluorescent carbon quantum dots with onion ring morphology and their usefulness as bioimaging agents |
|---|---|
| المؤلفون: | Herme G. Baldoví, Ana Blas-Garcia, José Raúl Herance, Miriam Polo, Victor M. Victor, Hermenegildo García |
| المصدر: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname |
| بيانات النشر: | Royal Society of Chemistry, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Morphology (linguistics), General Chemical Engineering, Nanoparticle, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, TOXICITY, HeLa, QUIMICA ORGANICA, SYSTEMS, Lewis acids and bases, GOLD, CELL, OXIDATIVE STRESS, DRUG-DELIVERY, biology, Chemistry, General Chemistry, 021001 nanoscience & nanotechnology, biology.organism_classification, Fluorescence, In vitro, MESOPOROUS HYDROXYAPATITE NANOPARTICLES, 0104 chemical sciences, Toxicity, Drug delivery, Biophysics, 0210 nano-technology |
| الوصف: | In the present work, two carbon quantum dots with onion ring morphology, C-NOR and C-NOR(Eu) with an average size of 40 nm differing in the absence or presence of Eu3+ as Lewis acids during their preparation were synthesized and fully characterized by several techniques. These nanoparticles can be internalized into human HeLa and Hep3B carcinoma cells where they exhibit interesting photoluminescent properties, in the same manner as in solution, confirming their utility as bioimaging agents. To address this possibility, a complete in vitro toxicological study has been performed here. Viability, proliferation, apoptosis and oxidative stress assessments upon limited or continuous exposure were done. It was observed that both nanoparticles did not show toxicity in both situations at low concentration, although some toxicity has been determined at higher concentrations under continuous exposure. These results support the possible use of C-NOR and C-NOR(Eu) nanoparticles as bioimaging agents. The present work was supported by grants CP13/00252, PI13/1025 from Carlos III Health Institute, and by the European Regional Development Fund (ERDF). In addition, this study was financed by the Spanish Ministry of Economy and Competitiveness (Severo Ochoa and CTQ-2012-32315), Generalitat Valenciana (Prometeo 2013/19), and FISABIO (UGP-14-95). This work was supported by the Ministerio de Economia y Competitividad (JCI-2012-15124 grant to A. B.-G.), and the Conselleria d'Educacio, Formacio i Ocupacio, Generalitat Valenciana (ACIF/2013/136 grant to M. P). V. M. V. is recipient of a contract from the Ministry of Health of the Valencian Regional Government and Carlos III Health Institute (CES10/030). |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b9315b751e6abe31dea22e6f6c8630 https://hdl.handle.net/10251/84255 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....03b9315b751e6abe31dea22e6f6c8630 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |