Toxicological Evaluation of Low Molecular Weight Fucoidan in Vitro and in Vivo
| العنوان: | Toxicological Evaluation of Low Molecular Weight Fucoidan in Vitro and in Vivo |
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| المؤلفون: | Hong-Ting Victor Lin, Yen-Chang Lin, Pai-An Hwang, Ming-De Yan, Kuan-Lun Li |
| المصدر: | Marine Drugs Marine Drugs; Volume 14; Issue 7; Pages: 121 Marine Drugs, Vol 14, Iss 7, p 121 (2016) |
| بيانات النشر: | MDPI, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Pharmaceutical Science, CHO Cells, Biology, Polysaccharide, Chromosome aberration, Article, low molecular weight fucoidan, Cell Line, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, toxicity, Laminaria japonica, Cricetulus, In vivo, Polysaccharides, Enzymatic hydrolysis, Drug Discovery, Animals, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), lcsh:QH301-705.5, chemistry.chemical_classification, Fucoidan, In vitro, Rats, Molecular Weight, 030104 developmental biology, Biochemistry, chemistry, lcsh:Biology (General), 030220 oncology & carcinogenesis, Micronucleus test, Toxicity, Dietary Supplements, Female, Laminaria |
| الوصف: | For a long time, fucoidan has been well known for its pharmacological activities, and recently low molecular weight fucoidan (LMF) has been used in food supplements and pharmaceutical products. In the present study, LMF was extracted from Laminaria japonica by enzyme hydrolysis. The toxicity of LMF in mouse and rat models was determined by many methods, such as total arsenic content, bacterial reverse mutation assay, chromosome aberration assay, and in vivo micronucleus assay. The present findings showed that LMF at 5000 μg/mL exhibited no mutagenicity. It also produced no formatting disruption of red blood cells in vivo. At 2000 mg/kg BW/day there were no toxicological indications. LMF is expected to be used as a safe food supplement. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1660-3397 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03bb3338047a2cba0813cf7ae3d9124d http://europepmc.org/articles/PMC4962011 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....03bb3338047a2cba0813cf7ae3d9124d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16603397 |
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