Pretransplant C3d-Fixing Donor-Specific Anti-HLA Antibodies Are Not Associated with Increased Risk for Kidney Graft Failure
| العنوان: | Pretransplant C3d-Fixing Donor-Specific Anti-HLA Antibodies Are Not Associated with Increased Risk for Kidney Graft Failure |
|---|---|
| المؤلفون: | Frederike J. Bemelman, Neelke C. van der Weerd, Bram W. Wisse, Luuk B. Hilbrands, Wendy Swelsen, Ineke J. M. ten Berge, Michiel G. H. Betjes, Arjan D. van Zuilen, Christina E.M. Voorter, Johan W. de Fijter, Arnold van der Meer, Henny G. Otten, Laura Bungener, Sebastiaan Heidt, Maarten H. L. Christiaans, Lotte Wieten, Wil A. Allebes, Marije C. Baas, Marc A. Seelen, M. Gelens, Dave L. Roelen, Elly M. van Duijnhoven, Karlijn A M I van der Pant, Frans J. van Ittersum, Bouke G. Hepkema, N M Lardy, Andries J. Hoitsma, Paul J M van der Boog, Franka E. van Reekum, Loes Plaisier, Caroline Roozendaal, Jan-Stephan F. Sanders, Annechien J. A. Lambeck, Elena G. Kamburova, Shaikh A. Nurmohamed, Michiel L. Bots, Cornelis E. Hack, Adriaan C.A.D. Drop, Frans H.J. Claas, Eric Spierings, Marcel G.J. Tilanus, Irma Joosten, Marianne C. Verhaar |
| المساهمون: | Internal Medicine, Nephrology, Amsterdam institute for Infection and Immunity, AII - Inflammatory diseases, APH - Aging & Later Life, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, MUMC+: DA Transplantatie Immunologie (5), MUMC+: DA TI Staf (9), MUMC+: DA TI Laboratorium (9), MUMC+: MA Nefrologie (9), Interne Geneeskunde, RS: NUTRIM - R3 - Respiratory & Age-related Health, Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), Clinical chemistry, Rehabilitation medicine, ACS - Atherosclerosis & ischemic syndromes, ACS - Diabetes & metabolism, AII - Infectious diseases, Internal medicine |
| المصدر: | Journal of the American Society of Nephrology, 29(9), 2279-2285. American Society of Nephrology Journal of the American Society of Nephrology, 29(9), 2279-2285 Journal of the American Society of Nephrology, 29, 2279-2285 Clinical journal of the American Society of Nephrology, 29(9), 2279-2285. American Society of Nephrology Journal of the American Society of Nephrology, 29(9), 2279-2285. AMER SOC NEPHROLOGY Kamburova, E G, Wisse, B W, Joosten, I, Allebes, W A, van der Meer, A, Hilbrands, L B, Baas, M C, Spierings, E, Hack, C E, van Reekum, F E, van Zuilen, A D, Verhaar, M C, Bots, M L, Drop, A C A D, Plaisier, L, Seelen, M A J, Sanders, J S, Hepkema, B G, Lambeck, A J A, Bungener, L B, Roozendaal, C, Tilanus, M G J, Voorter, C E, Wieten, L, van Duijnhoven, E M, Gelens, M A C J, Christiaans, M H L, van Ittersum, F J, Nurmohamed, S A, Lardy, N M, Swelsen, W, van der Pant, K A M I, van der Weerd, N C, Ten Berge, I J M, Bemelman, F J, Hoitsma, A J, van der Boog, P J M, de Fijter, J W, Betjes, M G H, Heidt, S, Roelen, D L, Claas, F H & Otten, H G 2018, ' Pretransplant C3d-Fixing Donor-Specific Anti-HLA Antibodies Are Not Associated with Increased Risk for Kidney Graft Failure ', Journal of the American Society of Nephrology, vol. 29, no. 9, pp. 2279-2285 . https://doi.org/10.1681/ASN.2018020205 Journal of the American Society of Nephrology, 29(9), 2279. American Society of Nephrology Journal of the American Society of Nephrology, 29, 9, pp. 2279-2285 |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Graft Rejection, Male, Nephrology, 030232 urology & nephrology, 030230 surgery, Gastroenterology, Cohort Studies, 0302 clinical medicine, HLA Antigens, Registries, Kidney transplantation, chronic allograft failure, Kidney, biology, Incidence, Hazard ratio, General Medicine, Middle Aged, Tissue Donors, Antibodies, Anti-Idiotypic, medicine.anatomical_structure, Complement C3d, SURVIVAL, Female, Antibody, Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5], Rapid Communication, Adult, medicine.medical_specialty, kidney transplantation, Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0], chemical and pharmacologic phenomena, Human leukocyte antigen, Risk Assessment, 03 medical and health sciences, Age Distribution, Transplantation Immunology, Internal medicine, Preoperative Care, medicine, Humans, Sex Distribution, Contraindication, Antilymphocyte Serum, Retrospective Studies, TRANSPLANTATION, business.industry, anti-HLA antibodies, medicine.disease, Transplant Recipients, body regions, Transplantation, RECIPIENTS, complement-fixing antibodies, C1Q ASSAY, biology.protein, Renal disorders Radboud Institute for Health Sciences [Radboudumc 11], business, Follow-Up Studies |
| الوصف: | Background Complement-fixing antibodies against donor HLA are considered a contraindication for kidney transplant. A modification of the IgG single-antigen bead (SAB) assay allows detection of anti-HLA antibodies that bind C3d. Because early humoral graft rejection is considered to be complement mediated, this SAB-based technique may provide a valuable tool in the pretransplant risk stratification of kidney transplant recipients.Methods Previously, we established that pretransplant donor-specific anti-HLA antibodies (DSAs) are associated with increased risk for long-term graft failure in complement-dependent cytotoxicity crossmatch-negative transplants. In this study, we further characterized the DSA-positive serum samples using the C3d SAB assay.Results Among 567 pretransplant DSA-positive serum samples, 97 (17%) contained at least one C3d-fixing DSA, whereas 470 (83%) had non-C3d-fixing DSA. At 10 years after transplant, patients with C3d-fixing antibodies had a death-censored, covariate-adjusted graft survival of 60%, whereas patients with non-C3d-fixing DSA had a graft survival of 64% (hazard ratio, 1.02; 95% confidence interval, 0.70 to 1.48 for C3d-fixing DSA compared with non-C3d-fixing DSA; P=0.93). Patients without DSA had a 10-year graft survival of 78%.Conclusions The C3d-fixing ability of pretransplant DSA is not associated with increased risk for graft failure. |
| وصف الملف: | image/pdf |
| تدمد: | 1046-6673 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041fae52c5d70ab1a03991ebda5d2f21 https://hdl.handle.net/2066/196423 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....041fae52c5d70ab1a03991ebda5d2f21 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10466673 |
|---|