Supplementary Figures and Tables from Coexpression of Inhibitory Receptors Enriches for Activated and Functional CD8+ T Cells in Murine Syngeneic Tumor Models
التفاصيل البيبلوغرافية
العنوان:
Supplementary Figures and Tables from Coexpression of Inhibitory Receptors Enriches for Activated and Functional CD8+ T Cells in Murine Syngeneic Tumor Models
American Association for Cancer Research (AACR), 2023.
سنة النشر:
2023
الوصف:
Supplemental Figures Showing: Fig. S1: CD8 T cells co-expressing PD1, LAG3 and TIM3 are present at different frequencies in MC38 and EMT6 tumors and represent activated cells. Fig. S2: CD8 T cells co-expressing inhibitory receptors are enriched in antigen-experienced and activated cells relative to the PD1- subset. Fig. S3: Majority of CD8 T cells in blood of MC38 and EMT6 tumor bearing mice lack PD1 and T-bet expression. Fig. S4: Anti-PD-L1 treatment increases the activity and cytolytic potential of PD1+ CD8 T cell subsets in MC38 and EMT6 tumors. Fig. S5: JC and 4T1 tumors do not respond to anti-PD-L1 treatment. Fig. S6: CD8 T cells co-expressing PD1, LAG3 and TIM3 are highly activated in JC and 4T1 tumors. Table S1: List of flow cytometry markers used for univariate linear regression analysis in Supplementary table 2. Table S2: Top parameters correlated with response to anti-PD-L1.
