Internal validation of STRmix™ – A multi laboratory response to PCAST

التفاصيل البيبلوغرافية
العنوان: Internal validation of STRmix™ – A multi laboratory response to PCAST
المؤلفون: Catherine McGovern, Scott McWilliams, John Buckleton, Simon Malsom, Christina Buettner, Anne Ciecko, George Duncan, Duncan Taylor, Vickie Beamer, Thomas Grill, Maarten Kruijver, Marla Kaplan, Ben Mallinder, Rebecca Richards, Claire McKenna, Naomi McDonald, Tamyra R. Moretti, Joshua Stewart, Jason Bundy, Steven Myers, Susan Welti, Shawn Montpetit, Melissa Strong, Hannah Kelly, Darren Wright, Craig O’Connor, Alan Magee, Deven Johnson, Brian Peck, John Lowe, Andrew McWhorter, Chase Baumgartner, Rachel H. Oefelein, Sarah Noël, Dorothy Catella, Tim Kalafut, Kathleen Corrado, Eugene Lien, Teresa McMahon, Paul Hulme, Jillian Echard, Colin Gallacher, Sheila Gentile, Mary Margaret Greer-Ritzheimer, Michelle Hassler, Jo-Anne Bright
بيانات النشر: Institute of Environmental Science and Research, 2019.
سنة النشر: 2019
مصطلحات موضوعية: 0301 basic medicine, Likelihood Functions, Genotype, DNA, Computational biology, Biology, DNA Fingerprinting, Pathology and Forensic Medicine, 03 medical and health sciences, Forensic dna, 030104 developmental biology, 0302 clinical medicine, Genetics, Humans, Multiplex, 030216 legal & forensic medicine, Internal validation, Laboratories, Forensic biology, Biological sciences, Genotyping, Alleles, Software, Microsatellite Repeats, Probability
الوصف: We report a large compilation of the internal validations of the probabilistic genotyping software STRmix™. Thirty one laboratories contributed data resulting in 2825 mixtures comprising three to six donors and a wide range of multiplex, equipment, mixture proportions and templates. Previously reported trends in the LR were confirmed including less discriminatory LRs occurring both for donors and non-donors at low template (for the donor in question) and at high contributor number. We were unable to isolate an effect of allelic sharing. Any apparent effect appears to be largely confounded with increased contributor number.
DOI: 10.26091/esrnz.10263239.v1
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04337fc1c5ab64b6a780a9c3f678fcbc
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....04337fc1c5ab64b6a780a9c3f678fcbc
قاعدة البيانات: OpenAIRE
الوصف
DOI:10.26091/esrnz.10263239.v1