Intrathecal humoral immune response in HAM/TSP in relation to HLA haplotype analysis
| العنوان: | Intrathecal humoral immune response in HAM/TSP in relation to HLA haplotype analysis |
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| المؤلفون: | M. Nakamura, Shunro Sonoda, M. Osame, S. Izumo, Koichiro Usuku, Toshinobu Fujiyoshi, S Ijichi, Shinji Yashiki, Bernd Kitze |
| المصدر: | Europe PubMed Central |
| بيانات النشر: | Hindawi Limited, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | viruses, Molecular Sequence Data, Human leukocyte antigen, Virus, Immunoenzyme Techniques, Immune system, HLA Antigens, immune system diseases, hemic and lymphatic diseases, Immunopathology, Tropical spastic paraparesis, Humans, Medicine, HLA Complex, biology, medicine.diagnostic_test, business.industry, virus diseases, General Medicine, medicine.disease, HTLV-I Infections, Virology, Paraparesis, Tropical Spastic, Haplotypes, Neurology, Immunoglobulin G, Immunoassay, Antibody Formation, Immunology, biology.protein, Neurology (clinical), Antibody, business |
| الوصف: | Introduction – In HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), we correlated human leukocyte antigen (HLA) haplotypes to the fine specificities of intrathecally synthesized IgG antibodies against HTLV-1. Patients and methods – HLA haplotypes of HAM/TSP patients were determined by the standard NIH microcytotoxicity test and family HLA studies. IgG antibodies against HTLV-1 synthetic peptides in paired CSF and serum were measured by enzyme immunoassay, and intrathecal synthesis of antibodies was evaluated. Results – HAM/TSP patients with particular HLA haplotypes (A24Cw7B7DR1DQ5, A2Cw7B7DR1DQ5, A24Cw-B52DR15DQ6, A11Cw1B54DR4DQ4, and A24CwlB54DR4DQ4) showed more frequently intrathecal synthesis of antibodies against HTLV-1 synthetic peptides, especially against HTLV-1 env gp21 synthetic peptides. Conclusion – In HAM/TSP, a retrovirus-induced human chronic inflammatory disease of the CNS, this is the first report to provide evidence that the intrathecal antiviral immune response is influenced by immunogenetic factors of the HLA complex. |
| تدمد: | 1600-0404 0001-6314 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04389628da4aaa66ebc62c285b1723a3 https://doi.org/10.1111/j.1600-0404.1996.tb07067.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....04389628da4aaa66ebc62c285b1723a3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16000404 00016314 |
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