Cigarette smoking, dietary habits and genetic polymorphisms inGSTT1,GSTM1andCYP1A1metabolic genes: A case-control study in oncohematological diseases
| العنوان: | Cigarette smoking, dietary habits and genetic polymorphisms inGSTT1,GSTM1andCYP1A1metabolic genes: A case-control study in oncohematological diseases |
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| المؤلفون: | Silvia Saba, Silvina Mariel Richard, Walter Hernán Pavicic, Graciela Klein, María Belén Cerliani, Juan Antonio Gili |
| المصدر: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET SEDICI (UNLP) Universidad Nacional de La Plata instacron:UNLP |
| بيانات النشر: | Baishideng Publishing Group Inc., 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, CYP1A1, Medicina Clínica, Bioinformatics, Oncología, purl.org/becyt/ford/1 [https], Genética y Herencia, 0302 clinical medicine, purl.org/becyt/ford/3.2 [https], Cyp1a1, Oncohematological disease, Cancer, GSTT1, integumentary system, purl.org/becyt/ford/3.1 [https], Bioquímica y Biología Molecular, respiratory system, Gstt1, Medicina Básica, Oncology, Casecontrol Study, 030220 oncology & carcinogenesis, purl.org/becyt/ford/3 [https], Oncohematological Disease, CIENCIAS NATURALES Y EXACTAS, CIENCIAS MÉDICAS Y DE LA SALUD, Xenobiotic metabolizing genes, Xenobiotic Metabolizing Genes, Ciencias Biológicas, Casecontrol study, 03 medical and health sciences, Cigarette smoking, Tobacco, medicine, purl.org/becyt/ford/1.6 [https], neoplasms, Gene, Ciencias Exactas, business.industry, Case-control study, Lifestyle, medicine.disease, Diet, Gstm1, 030104 developmental biology, Ciencias Médicas, business, GSTM1 |
| الوصف: | Aim: To analyze the association between oncohematological diseases and GSTT1 /GSTM1 /CYP1A1 polymorphisms, dietary habits and smoking, in an argentine hospitalbased case-control study. Methods: This hospital-based case-control study involved 125 patients with oncohematological diseases and 310 control subjects. A questionnaire was used to obtain sociodemographic data and information about habits. Blood samples were collected, and DNA was extracted using salting out methods. Deletions in GSTT1 and GSTM1 (null genotypes) were addressed by PCR. CYP1A1 MspI polymorphism was detected by PCR-RFLP. Odds ratio (OR) and 95%CI were calculated to estimate the association between each variable studied and oncohematological disease. Results: Women showed lower risk of disease compared to men (OR 0.52, 95%CI: 0.34-0.82, P = 0.003). Higher levels of education (> 12 years) were significantly associated with an increased risk, compared to complete primary school or less (OR 3.68, 95%CI: 1.82-7.40, P < 0.001 adjusted for age and sex). With respect to tobacco, none of the smoking categories showed association with oncohematological diseases. Regarding dietary habits, consumption of grilled/barbecued meat 3 or more times per month showed significant association with an increased risk of disease (OR 1.72, 95%CI: 1.08-2.75, P = 0.02). Daily consumption of coffee also was associated with an increased risk (OR 1.77, 95%CI: 1.03-3.03, P = 0.03). Results for GSTT1, GSTM1 and CYP1A1 polymorphisms showed no significant association with oncohematological diseases. When analyzing the interaction between polymorphisms and tobacco smoking or dietary habits, no statistically significant associations that modify disease risk were found. Conclusion: We reported an increased risk of oncohematological diseases associated with meat and coffee intake. We did not find significant associations between genetic polymorphisms and blood cancer. Instituto Multidisciplinario de Biología Celular |
| وصف الملف: | application/pdf |
| تدمد: | 2218-4333 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0447965e929f7f351d53191a2c751db6 https://doi.org/10.5306/wjco.v7.i5.395 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0447965e929f7f351d53191a2c751db6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22184333 |
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