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Sertraline demonstrates fungicidal activity in vitro for Coccidioides immitis

التفاصيل البيبلوغرافية
العنوان: Sertraline demonstrates fungicidal activity in vitro for Coccidioides immitis
المؤلفون: Roger B. Mortimer, Marilyn Mitchell, Simon Paul
المصدر: Mycology, Vol 7, Iss 3, Pp 99-101 (2016)
بيانات النشر: Informa UK Limited, 2016.
سنة النشر: 2016
مصطلحات موضوعية: 0301 basic medicine, Coccidioides immitis, coccidioidomycosis, 030106 microbiology, lcsh:QR1-502, Disseminated coccidioidomycosis, Pharmacology, Microbiology, lcsh:Microbiology, 03 medical and health sciences, Minimum inhibitory concentration, In vivo, Sertraline, fluconazole, medicine, Coccidioides, MIC, lcsh:QH301-705.5, biology, meningitis, biology.organism_classification, medicine.disease, In vitro, Infectious Diseases, lcsh:Biology (General), Fluconazole, medicine.drug
الوصف: Coccidioidomycosis causes substantial morbidity in endemic areas. Disseminated coccidioidomycosis is an AIDS defining condition and treatment often requires lifelong antifungal therapy. Sertraline, a widely used serotonin-reuptake inhibitor anti-depressant, has demonstrated activity against Candida and Cryptococcus sp. both in vitro and in vivo. To evaluate if sertraline has activity against Coccidioides, the minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) of sertraline for four clinical isolates of C. immitis were determined. Sertraline was observed to have an MIC range of 4–8 µg/ml and MFC also of 4–8 µg/ml for Coccidioides. These MIC and MFC results for C. immitis are similar to those reported for Cryptococcus sp. suggesting sertraline may potentially have utility for the treatment of coccidioidomycosis.
تدمد: 2150-1211
2150-1203
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046ddb5cc0e55bd53be306daac973960
https://doi.org/10.1080/21501203.2016.1204368
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....046ddb5cc0e55bd53be306daac973960
قاعدة البيانات: OpenAIRE
الوصف
تدمد:21501211
21501203