Heritability of Subclinical Atherosclerosis in Latino Families Ascertained Through a Hypertensive Parent
| العنوان: | Heritability of Subclinical Atherosclerosis in Latino Families Ascertained Through a Hypertensive Parent |
|---|---|
| المؤلفون: | Willa A. Hsueh, Ci-hua Liu, Stanley P. Azen, Leslie J. Raffel, Howard N. Hodis, Thomas A. Buchanan, Justo Diaz, Lawrence W. Castellani, Anny H. Xiang, Sylvia Tan, Chi-Hua Liu, Jerome I. Rotter, Linguen Cheng, M. Quinonnes, Edgar Toscano |
| المصدر: | Arteriosclerosis, Thrombosis, and Vascular Biology. 22:843-848 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Adult, Male, Parents, Proband, Tunica media, medicine.medical_specialty, Adolescent, Arteriosclerosis, Carotid Artery, Common, Offspring, Coronary Disease, Quantitative Trait, Heritable, Internal medicine, Mexican Americans, medicine, Humans, Genetic Predisposition to Disease, cardiovascular diseases, Risk factor, Aged, Likelihood Functions, business.industry, Hispanic or Latino, Middle Aged, Heritability, medicine.anatomical_structure, Blood pressure, Endocrinology, Intima-media thickness, Hypertension, Multivariate Analysis, cardiovascular system, Female, Tunica Intima, Tunica Media, Cardiology and Cardiovascular Medicine, business, Body mass index, Demography |
| الوصف: | Although clinical coronary heart disease and many cardiovascular risk factors are well known to aggregate within families, the heritability of carotid artery intima-media thickness (IMT) is less well documented. We report IMT heritability estimates in Mexican American, Salvadoran American, or Guatemalan American (all referred to as Latino) families ascertained through a hypertensive proband. IMT and cardiovascular risk factors (age, sex, blood pressure, body mass index, lipids, fasting glucose, and insulin sensitivity) were measured in 204 adult offspring of 69 hypertensive probands, along with 82 parents (54 probands and 28 spouses). In the offspring, variance component analysis revealed a heritability for IMT of 64% ( P < 0.0001) after adjustment for significant cardiovascular risk factors. Genetic factors accounted for 50% of the total variation in IMT, whereas significant cardiovascular risk factors explained 22% (14% were due to age). For offspring and parents combined, adjusted IMT heritability was less, 34% ( P =0.0005), with genetic factors accounting for 18% of the total IMT variation, whereas significant cardiovascular risk factors explained 46% (38% were due to age). We conclude that variation in c ommon carotid artery IMT is heritable in Latino families with a hypertensive proband. Heritability is particularly evident in younger family members, suggesting that acquired factors contribute progressively to IMT variability with aging. |
| تدمد: | 1524-4636 1079-5642 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ab5b39bd52255dd0fa2ba9a620e13a https://doi.org/10.1161/01.atv.0000015329.15481.e8 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....04ab5b39bd52255dd0fa2ba9a620e13a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244636 10795642 |
|---|