Slow integrin-dependent migration organizes networks of tissue-resident mast cells
| العنوان: | Slow integrin-dependent migration organizes networks of tissue-resident mast cells |
|---|---|
| المؤلفون: | Lukas Kaltenbach, Paloma Martzloff, Sarah K. Bambach, Nadim Aizarani, Michael Mihlan, Alina Gavrilov, Katharina M. Glaser, Manuel Stecher, Roland Thünauer, Aude Thiriot, Klaus Heger, Katrin Kierdorf, Stephan Wienert, Ulrich H. von Andrian, Marc Schmidt-Supprian, Claus Nerlov, Frederick Klauschen, Axel Roers, Marc Bajénoff, Dominic Grün, Tim Lämmermann |
| المساهمون: | Max Planck Institute of Immunobiology and Epigenetics (MPI-IE), Max-Planck-Gesellschaft, International Max Planck Research School for Immunobiology (IMPRS-IEM freburg), Faculty of Biology, University of Freiburg, Friedrich Miescher Institute for Biomedical Research (FMI), Novartis Research Foundation, Centre for Structural Systems Biology hamburg (Advanced Light and Fluorescence Microscopy Facility), Harvard Medical School [Boston] (HMS), The Ragon Institute of MGH, Department of Cancer Immunology, South San Francisco (Genentech), University of Freiburg [Freiburg], Centre for Integrative Biological Signalling Studies [Freiburg] (CIBSS), Center for Basics in NeuroModulation - Faculty Medicine - University of Freiburg (NeuroModulBasics), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Center for Translational Cancer Research - Munich (TranslaTUM), MRC Weatherall Institute of Molecular Medicine - John Radcliffe Hospital, Ludwig-Maximilians University [Munich] (LMU), Berlin Institute for the Foundation of Learning and Data - Berlin (BIFOLD), UniversitätsKlinikum Heidelberg, Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Julius-Maximilians-Universität Würzburg (JMU), University of Würzburg = Universität Würzburg, Helmholtz Institute for RNA‐based Infection Research (HIRI) |
| المصدر: | Nature Immunology Nature Immunology, 2023, 24, pp.915-924. ⟨10.1038/s41590-023-01493-2⟩ |
| بيانات النشر: | HAL CCSD, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Innate immune cells, [SDV]Life Sciences [q-bio], Immunology, Immunology and Allergy, Imaging the immune system, Cell migration |
| الوصف: | Immune cell locomotion is associated with amoeboid migration, a flexible mode of movement, which depends on rapid cycles of actin polymerization and actomyosin contraction1. Many immune cells do not necessarily require integrins, the major family of adhesion receptors in mammals, to move productively through three-dimensional tissue spaces2,3. Instead, they can use alternative strategies to transmit their actin-driven forces to the substrate, explaining their migratory adaptation to changing external environments4–6. However, whether these generalized concepts apply to all immune cells is unclear. Here, we show that the movement of mast cells (immune cells with important roles during allergy and anaphylaxis) differs fundamentally from the widely applied paradigm of interstitial immune cell migration. We identify a crucial role for integrin-dependent adhesion in controlling mast cell movement and localization to anatomical niches rich in KIT ligand, the major mast cell growth and survival factor. Our findings show that substrate-dependent haptokinesis is an important mechanism for the tissue organization of resident immune cells. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1529-2908 1529-2916 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d1b64309963a8263cb0f2d5a0ac0fe https://amu.hal.science/hal-04155979/document |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....04d1b64309963a8263cb0f2d5a0ac0fe |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15292908 15292916 |
|---|