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Comparison of the effect of isotretionin and alitretionin on endometriotic implants and serum vascular endothelial growth factor level: an experimental study

التفاصيل البيبلوغرافية
العنوان: Comparison of the effect of isotretionin and alitretionin on endometriotic implants and serum vascular endothelial growth factor level: an experimental study
المؤلفون: Orhan Deger, Umit Cobanoglu, Cavit Kart, Kübra Akbulut, Suleyman Guven, Deniz Kulaksiz
المصدر: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 35(4)
سنة النشر: 2019
مصطلحات موضوعية: Vascular Endothelial Growth Factor A, medicine.medical_specialty, medicine.drug_class, Endocrinology, Diabetes and Metabolism, VEGF receptors, education, Endometriosis, Drug Evaluation, Preclinical, 030209 endocrinology & metabolism, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Internal medicine, medicine, Animals, Retinoid, Isotretinoin, Alitretinoin, 030219 obstetrics & reproductive medicine, biology, business.industry, Obstetrics and Gynecology, medicine.disease, Vascular endothelial growth factor, chemistry, biology.protein, Female, business
الوصف: To compare the effects of alitretionin and isotretionin on endometrial peritoneal implants and serum vascular endothelial growth factor (VEGF) levels.Forty-eight female Sprague Dawley rats were used. Initially surgical rat endometriosis model was done. The endometrial implant volume was measured and rats were randomly divided into four groups. Group 1: Control group (rats did not get any drug but having endometriotic implants), group 2: rats receiving po isotretionin 10 mg/kg per day for 10 d, group 3: rats receiving po isotretionin 20 mg/kg per day for 10 d and group 4: rats receiving po alitretionin 80 mg/kg per day for 10 d. After 1-week medication, rats were sacrificed and size, histopathology of endometriotic implant and levels of VEGF were evaluated.Volumes of peritoneal endometrial implants were significantly decreased in Group 2 and Group 3 compared with initial values. However, there were no significant changes in histopathological scores and serum VEGF levels in all groups.This study finding may suggest the possible medical treatment modality of isotretionin on endometriosis. However, alitretionin (potent retinoid) does not have potent regressive effect on endometriotic implants as in isotretionin.
تدمد: 1473-0766
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::050977e52bc70015e33b2295edd30ca9
https://pubmed.ncbi.nlm.nih.gov/30600729
رقم الأكسشن: edsair.doi.dedup.....050977e52bc70015e33b2295edd30ca9
قاعدة البيانات: OpenAIRE
الوصف
تدمد:14730766