The gelatin-derived plasma substitute Gelofusine causes low-molecular-weight proteinuria by decreasing tubular protein reabsorption
| العنوان: | The gelatin-derived plasma substitute Gelofusine causes low-molecular-weight proteinuria by decreasing tubular protein reabsorption |
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| المؤلفون: | Jack F.M. Wetzels, Ina S. Klasen, Amanda J.W. Branten, Marc A.G.J. ten Dam |
| المصدر: | Journal of Critical Care, 16, 3, pp. 115--20 Journal of Critical Care, 16, 115--20 |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Gelofusine, Plasma Substitutes, Renal function, Hemodynamics, Pathofysiologie, immunologie en behandeling van nieraandoeningen, Ontwikkeling en kwaliteitsborging in de laboratoriumgeneeskunde, Critical Care and Intensive Care Medicine, Innovation and Quality assurance in laboratory medicine, Excretion, Internal medicine, medicine, Humans, Netherlands, Proteinuria, business.industry, Reabsorption, Albumin, Proteins, Succinates, Effective renal plasma flow, Pathophysiology, immunology and treatment of renal disease, Molecular Weight, Endocrinology, Kidney Tubules, Gelatin, medicine.symptom, business |
| الوصف: | Item does not contain fulltext PURPOSE: Proteinuria is frequently encountered in patients in the intensive care unit, most likely as a result of renal tubular cell injury. It has been reported that gelatin-derived plasma substitutes contribute to an increase in renal protein excretion. The aim of this study was to investigate the magnitude and the mechanism of the proteinuric effect of Gelofusine, a modified gelatin. MATERIALS AND METHODS: In six healthy male subjects, renal hemodynamics and urinary protein excretion were measured before and after infusion of 330 mL of Gelofusine. RESULTS: Gelofusine had a minor effect on blood pressure, glomerular filtration rate, effective renal plasma flow, and on urinary excretion of immunoglobulin, and albumin. In contrast, there was a major increase in the urinary excretion of the low-molecular-weight proteins beta2-microglobulin (from 0.06 +/- 0.04 to 43.52 +/- 11.75 microg/min; P |
| تدمد: | 0883-9441 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051621b7d7162db05d87a94f288814f4 https://pubmed.ncbi.nlm.nih.gov/11689768 |
| حقوق: | RESTRICTED |
| رقم الأكسشن: | edsair.doi.dedup.....051621b7d7162db05d87a94f288814f4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 08839441 |
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