Persistent inflammation alters the function of the endogenous brain stem cell compartment
| العنوان: | Persistent inflammation alters the function of the endogenous brain stem cell compartment |
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| المؤلفون: | Giuliana Salani, Samia J. Khoury, Stefano Pluchino, Cristina Porcheri, Francesca Cavasinni, Michela Deleidi, Clara Alfaro-Cervello, Luca Muzio, José Manuel García-Verdugo, Andrea Bergamaschi, Elena Brambilla, Gianvito Martino, Jaime Imitola, Giancarlo Comi |
| المساهمون: | Pluchino, S, Muzio, L, Imitola, J, Deleidi, M, Alfaro Cervello, C, Salani, G, Porcheri, C, Brambilla, E, Cavasinni, F, Bergamaschi, A, Garcia Verdugo, Jm, Khoury, Sj, Comi, G, Martino, G |
| المصدر: | BRAIN r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) Centro de Investigación Principe Felipe (CIPF) r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) instname Brain |
| بيانات النشر: | Oxford University Press (OUP), 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Encephalomyelitis, Autoimmune, Experimental, experimental autoimmune encephalomyelitis, Subventricular zone, Inflammation, Biology, multiple sclerosis, Mice, 03 medical and health sciences, 0302 clinical medicine, Neuroblast, Cell Movement, Precursor cell, ischemic stroke, medicine, Animals, Cells, Cultured, Tissue homeostasis, Cell Proliferation, neural stem cells, 030304 developmental biology, 0303 health sciences, Stem Cells, Cell Cycle, Neurogenesis, Original Articles, brain cell stem, Neural stem cell, Clone Cells, Nerve Regeneration, Mice, Inbred C57BL, Microscopy, Electron, neurogenesis, medicine.anatomical_structure, inflammation, Chronic Disease, Models, Animal, Cytokines, Female, Neurology (clinical), Stem cell, medicine.symptom, Neuroscience, 030217 neurology & neurosurgery, Brain Stem |
| الوصف: | Endogenous neural stem/precursor cells (NPCs) are considered a functional reservoir for promoting tissue homeostasis and repair after injury, therefore regenerative strategies that mobilize these cells have recently been proposed. Despite evidence of increased neurogenesis upon acute inflammatory insults (e.g. ischaemic stroke), the plasticity of the endogenous brain stem cell compartment in chronic CNS inflammatory disorders remains poorly characterized. Here we show that persistent brain inflammation, induced by immune cells targeting myelin, extensively alters the proliferative and migratory properties of subventricular zone (SVZ)-resident NPCs in vivo leading to significant accumulation of non-migratory neuroblasts within the SVZ germinal niche. In parallel, we demonstrate a quantitative reduction of the putative brain stem cells proliferation in the SVZ during persistent brain inflammation, which is completely reversed after in vitro culture of the isolated NPCs. Together, these data indicate that the inflamed brain microenvironment sustains a non cell-autonomous dysfunction of the endogenous CNS stem cell compartment and challenge the potential efficacy of proposed therapies aimed at mobilizing endogenous precursors in chronic inflammatory brain disorders. |
| تدمد: | 1460-2156 0006-8950 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05254597e3548d254ad2593c32b66f84 https://doi.org/10.1093/brain/awn198 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....05254597e3548d254ad2593c32b66f84 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602156 00068950 |
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