Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect
| العنوان: | Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect |
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| المؤلفون: | Henrik Walter, Frauke Nees, Sabina Millenet, Dimitri Papadopoulos Orfanos, Penny A. Gowland, Andreas Heinz, Eric Artiges, Juliane H. Fröhner, Bernd Ittermann, Boris William Böttinger, Erin Burke Quinlan, Luise Poustka, Daniel Brandeis, Tomáš Paus, Robert Whelan, Gareth J. Barker, Tobias Banaschewski, Jean-Luc Martinot, Michael N. Smolka, Sarah Baumeister, Hugh Garavan, Herta Flor, Antoine Grigis, Sylvane Desrivières, Arun L.W. Bokde, Gunter Schumann, Marie-Laure Paillère Martinot, Christian Büchel |
| المساهمون: | Universität Heidelberg, Ecole des Neurosciences de Paris Île de France (ENP), Ecole des Neurosciences de Paris |
| المصدر: | European Child and Adolescent Psychiatry European Child and Adolescent Psychiatry, Springer Verlag (Germany), In press, ⟨10.1007/s00787-021-01770-1⟩ European Child & Adolescent Psychiatry, 31 (8) |
| بيانات النشر: | HAL CCSD, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Conduct Disorder, Male, medicine.medical_specialty, Adolescent, Prefrontal Cortex, Subclinical, Audiology, Adolescence, Conduct problems, Affective processing, Orbitofrontal cortex, FMRI, 03 medical and health sciences, Functional brain, 0302 clinical medicine, Linear regression, Developmental and Educational Psychology, Medicine, Humans, 0501 psychology and cognitive sciences, In patient, Subclinical infection, Problem Behavior, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, Facial affect, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, business.industry, 05 social sciences, Brain, General Medicine, Magnetic Resonance Imaging, Facial Expression, Psychiatry and Mental health, Multicenter study, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Pediatrics, Perinatology and Child Health, Female, Analysis of variance, business, 030217 neurology & neurosurgery, 050104 developmental & child psychology |
| الوصف: | Conduct problems (CP) in patients with disruptive behavior disorders have been linked to impaired prefrontal processing of negative facial affect compared to controls. However, it is unknown whether associations with prefrontal activity during affective face processing hold along the CP dimension in a healthy population sample, and how subcortical processing is affected. We measured functional brain responses during negative affective face processing in 1444 healthy adolescents [M = 14.39 years (SD = 0.40), 51.5% female] from the European IMAGEN multicenter study. To determine the effects of CP, we applied a two-step approach: (a) testing matched subgroups of low versus high CP, extending into the clinical range [N = 182 per group, M = 14.44 years, (SD = 0.41), 47.3% female] using analysis of variance, and (b) considering (non)linear effects along the CP dimension in the full sample and in the high CP group using multiple regression. We observed no significant cortical or subcortical effect of CP group on brain responses to negative facial affect. In the full sample, regression analyses revealed a significant linear increase of left orbitofrontal cortex (OFC) activity with increasing CP up to the clinical range. In the high CP group, a significant inverted u-shaped effect indicated that left OFC responses decreased again in individuals with high CP. Left OFC activity during negative affective processing which is increasing with CP and decreasing in the highest CP range may reflect on the importance of frontal control mechanisms that counteract the consequences of severe CP by facilitating higher social engagement and better evaluation of social content in adolescents. European Child & Adolescent Psychiatry, 31 (8) ISSN:1435-165X ISSN:1018-8827 |
| وصف الملف: | application/application/pdf |
| اللغة: | English |
| تدمد: | 1435-165X 1018-8827 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b7561604a3eb90696557807f8393b9 https://hal-univ-paris.archives-ouvertes.fr/hal-03240430/document |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....05b7561604a3eb90696557807f8393b9 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 1435165X 10188827 |
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