The role of lysosomes in cancer development and progression
| العنوان: | The role of lysosomes in cancer development and progression |
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| المؤلفون: | Xian-yan Yang, Ze-Yu Yang, Jun Wang, Shi-cang Yu, Qian Wen, Di Wang, Lin Li, Tao Tang, Xiu-Wu Bian, Lei Gao |
| المصدر: | Cell & Bioscience Cell & Bioscience, Vol 10, Iss 1, Pp 1-18 (2020) |
| بيانات النشر: | BioMed Central, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Angiogenesis, lcsh:Biotechnology, Antigen presentation, Cell, Review, Biology, Exosome, General Biochemistry, Genetics and Molecular Biology, Metastasis, lcsh:Biochemistry, lcsh:TP248.13-248.65, medicine, lcsh:QD415-436, Spatial distribution, Cell adhesion, lcsh:QH301-705.5, Cancer, Plasma membrane repair, Energy metabolism, medicine.disease, Cell biology, medicine.anatomical_structure, lcsh:Biology (General), Lysosomes |
| الوصف: | Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release, cell adhesion/migration and apoptosis. Thus, lysosomes play important roles in cellular activity. In addition, previous studies have shown that lysosomes may play important roles in cancer development and progression through the abovementioned biological processes and that the functional status and spatial distribution of lysosomes are closely related to cancer cell proliferation, energy metabolism, invasion and metastasis, immune escape and tumor-associated angiogenesis. Therefore, identifying the factors and mechanisms that regulate the functional status and spatial distribution of lysosomes and elucidating the relationship between lysosomes and the development and progression of cancer can provide important information for cancer diagnosis and prognosis prediction and may yield new therapeutic targets. This study briefly reviews the above information and explores the potential value of lysosomes in cancer therapy. |
| اللغة: | English |
| تدمد: | 2045-3701 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e5680b1ed8b276223be691469cfce6 http://europepmc.org/articles/PMC7677787 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....05e5680b1ed8b276223be691469cfce6 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 20453701 |
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