Diffusion Kinetics in Blood during Haemodialysis and in vivo Clearance of Inorganic Phosphate
| العنوان: | Diffusion Kinetics in Blood during Haemodialysis and in vivo Clearance of Inorganic Phosphate |
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| المؤلفون: | Eric Descombes, André Jutzet, François Perriard, Gilbert Fellay |
| المصدر: | Blood Purification. 19:4-9 |
| بيانات النشر: | S. Karger AG, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Erythrocytes, Time Factors, Chromatography, Chemistry, medicine.medical_treatment, Diffusion, Kinetics, Hematology, General Medicine, Phosphate, Phosphates, Red blood cell, chemistry.chemical_compound, Blood, medicine.anatomical_structure, Renal Dialysis, Nephrology, In vivo, medicine, Humans, Hemodialysis, Dialysis (biochemistry), Blood drawing |
| الوصف: | Contradictory data are reported in the literature concerning the diffusion kinetics of inorganic phosphates (iPh) between red blood cells and plasma during haemodialysis. Accordingly, we performed mass balance and equilibration studies to analyze the diffusion kinetics of iPh in vivo and in vitro. Mass balance analysis shows that iPh is only cleared from the plasma volume and thus that it practically does not diffuse from red blood cells to plasma during the short time lapse of blood transit through the haemodialyzer. In vitro equilibration studies of blood drawn at the filter outlet show that at room temperature there is a slow, limited, and almost linear net efflux of iPh during the 4 h that follow blood drawing. Our results point out: (1) that the in vivo clearance of iPh should be exclusively determined as plasma clearance, and (2) that for accurate clearance determinations the iPh concentrations should be measured in blood samples centrifuged within at most 1 h after blood drawing. Whole-blood clearance determinations – as well as the in vitro dialyzer data – largely overestimate (>30%) the real in vivo dialyzer performance. |
| تدمد: | 1421-9735 0253-5068 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06267a9365dafa79a7acaf8024f6ddff https://doi.org/10.1159/000014470 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....06267a9365dafa79a7acaf8024f6ddff |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219735 02535068 |
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