N-Acetylcysteine anAlliumPlant Compound Improves High-Sucrose Diet-Induced Obesity and Related Effects
| العنوان: | N-Acetylcysteine anAlliumPlant Compound Improves High-Sucrose Diet-Induced Obesity and Related Effects |
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| المؤلفون: | Gisele A. Souza, Fernanda Mani, Ethel L. B. Novelli, Fábio Rodrigues Ferreira Seiva, Geovana Xavier Ebaid, Katiucha H. R. Rocha, Cristiano M. Galhardi |
| المساهمون: | Universidade Estadual Paulista (Unesp) |
| المصدر: | Evidence-Based Complementary and Alternative Medicine, Vol 2011 (2011) Evidence-based Complementary and Alternative Medicine : eCAM Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| بيانات النشر: | Hindawi Limited, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | medicine.medical_specialty, Very low-density lipoprotein, Antioxidant, medicine.diagnostic_test, medicine.medical_treatment, lcsh:Other systems of medicine, Glutathione, lcsh:RZ201-999, medicine.disease_cause, Feed conversion ratio, chemistry.chemical_compound, Endocrinology, Complementary and alternative medicine, chemistry, In vivo, Internal medicine, medicine, Original Article, Lipid profile, Oxidative stress, Lipoprotein |
| الوصف: | Made available in DSpace on 2013-08-28T14:10:23Z (GMT). No. of bitstreams: 1 WOS000293522100001.pdf: 1692448 bytes, checksum: bb02a8558f8636831fd89c393d7c482f (MD5) Made available in DSpace on 2013-09-30T18:40:52Z (GMT). No. of bitstreams: 2 WOS000293522100001.pdf: 1692448 bytes, checksum: bb02a8558f8636831fd89c393d7c482f (MD5) WOS000293522100001.pdf.txt: 37057 bytes, checksum: caa80a6dbddf45d11214ae02be2e0ff5 (MD5) Previous issue date: 2011-01-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:53:40Z No. of bitstreams: 2 WOS000293522100001.pdf: 1692448 bytes, checksum: bb02a8558f8636831fd89c393d7c482f (MD5) WOS000293522100001.pdf.txt: 37057 bytes, checksum: caa80a6dbddf45d11214ae02be2e0ff5 (MD5) Made available in DSpace on 2014-05-20T13:53:40Z (GMT). No. of bitstreams: 2 WOS000293522100001.pdf: 1692448 bytes, checksum: bb02a8558f8636831fd89c393d7c482f (MD5) WOS000293522100001.pdf.txt: 37057 bytes, checksum: caa80a6dbddf45d11214ae02be2e0ff5 (MD5) Previous issue date: 2011-01-01 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) This study was designed to determine whether N-acetylcysteine (NAC, C(5)H(9)-NO(3)S), a compound from Allium species may be used as a complementary therapeutic agent, to inhibit high-sucrose induced-obesity and its effects on glucose tolerance, in vivo low-density lipoprotein (LDL)-oxidation and serum oxidative stress in rats. Initially, 24 male Wistar rats were divided into two groups: controls receiving standard chow (C, n = 6) and those receiving high-sucrose diet (HS, n = 18). After 22 days, (HS) group was divided into three groups (n = 6/group); (HS-HS) continued to eat high-sucrose diet and water; (HS-N) continued to eat high-sucrose diet and received 2 mg l(-1)-NAC in its drinking water; (HS-CN) changing high-sucrose to standard chow and receiving 2 mg l(1)-NAC in its drinking water. After 22 days of the HS-group division (44 days of experimental period) body weight, body mass index and surface area were enhanced in HS-HS rats (P < .001). HS-HS rats had glucose intolerance, increased serum triacylglycerol (TG), very low-density lipoprotein (VLDL), oxidized-LDL (ox-LDL) and lipid-hydroperoxide (LH) than the others (P < .01). NAC in HS-N and HS-CN rats reduced the obesity markers, feed efficiency, LH and ox-LDL, as well normalized glucose response, TG and VLDL (P < .01) in these groups compared with HS-HS. Total antioxidant substances, GSH/GSSG ratio and glutathione-reductase, were higher in HS-N than in HS-HS (P < .01). In conclusion, NAC improved high-sucrose diet-induced obesity and its effects on glucose tolerance, lipid profile, in vivo LDL-oxidation and serum oxidative stress, enhancing antioxidant defences. The application of this agent may be feasible and beneficial for high-sucrose diet-induced obesity, which certainly would bring new insights on obesity-related adverse effects control. São Paulo State Univ, Inst Biosci, Dept Chem & Biochem, UNESP, BR-18618000 São Paulo, Brazil São Paulo State Univ, Sch Med, UNESP, Dept Clin & Cardiol,Post Grad Course, BR-18618000 São Paulo, Brazil São Paulo State Univ, Inst Biosci, Dept Chem & Biochem, UNESP, BR-18618000 São Paulo, Brazil São Paulo State Univ, Sch Med, UNESP, Dept Clin & Cardiol,Post Grad Course, BR-18618000 São Paulo, Brazil |
| تدمد: | 1741-4288 1741-427X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0661c22a11f9554984e76c8a6741f0ca https://doi.org/10.1093/ecam/nen070 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....0661c22a11f9554984e76c8a6741f0ca |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17414288 1741427X |
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